ISBN13:978-0805330663 ISBN10: 0805330666 This edition has also been released as: ISBN13: 978-0805330724 ISBN10: 0805330720
Summary: Biochemistry, Third Edition merges a classical organization and presentation with contemporary insight, information, and technology, to make modern biochemistry interesting and accessible to today's students. Thoroughly updated to include the latest information, perspectives, and experimental techniques, the text is now supported by integrated media resources designed by the new co-author Kevin Ahern. Together, the text and media resources provide students and...show more instructors with a doorway to the vast world of biochemistry that is continuously evolving and which greatly exceeds what could be covered in a conventional textbook alone. As in previous editions, the authors introduce nucleic acid structure early (to clarify presentations of protein structure and function), emphasize the experimental roots of biochemistry (past and present), continually emphasize the energy relationships in biochemistry, and take a stepwise approach to complex metabolic pathways. The result is a thorough grounding in biology at the atomic/molecular level. The explosive growth of biochemistry, molecular biology, and biotechnology makes this approach particularly relevant for today's life science students.
New accompanying media resources. Created by new co-author, Kevin Ahern, a Web site and CD-ROMs provide a valuable resource for students and instructors. Includes animations of difficult processes, maps of metabolic pathways with links to pertinent enzymes and intermediates, diagnostic quizzes, structures of molecules described in the text, an expanded Tools section with links to online techniques and databases used by biochemists, medical applications related to biochemical topics covered in the text, links to important biomedical sites, and more.
Keeping current with today's discoveries. This edition is thoroughly updated with the latest information, perspectives, and techniques in biochemistry. Examples include expanded discussion of protein folding and chaperone proteins (Chapter 6); molecular motors (Chapter 8); structures of mitochondrial respiratory complexes (Chapter 15); reactive oxygen species and human disease (Chapter 15); biochemical insights into obesity (Chapter 18); folic acid, vitamin B12, and the heart (Chapter 20); neurotransmitters and psychopharmacology (Chapter 21), new signal transduction pathways (Chapter 23); structures and mechanisms of DNA polymerases (Chapter 24); and eukaryotic gene expression (Chapter 28).
Enhanced accessibility while maintaining rigor. Bioenergetics introduced in Chapter 3 (i.e., the role of ATP as energy currency) is now covered later in the text in Chapter 12, removing some redundancy and enhancing accessibility. Each topic in the text is now introduced with an overview that outlines the material to be covered and highlights essential points.
Updated "Tools" of Biochemistry sections. A new section has been added on methods for detecting and analyzing protein-protein interactions. Modern variants of older techniques have been added, such as the sections on laser scanning confocal microscopy (Chapter 1) and the synthesis of combinatorial arrays of peptides (Chapter 5). The section on mass spectrometry (Chapter 6) has been expanded to reflect its growing importance and versatility. All Tools sections are supplemented with exercises, demonstrations, and links on the Web site.
More life science applications. The number of real-life clinical examples have been increased to include such topics as ribozymes as antiviral drugs (Chapter 11), dopamine receptors and drug addiction (Chapter 21), and telomerase and cancer (Chapter 28).
New problems test understanding. Most chapters include two to four new quantitative and discussion-type questions, with brief answers to all problems provided in the appendix.
Remarkable artwork. Many illustrations summarize individual topics and each chapter's art forms a coherent story that augments the textual presentation and allows students to easily review the content.
Complex metabolic pathways are presented step by step: introduction, followed by an overview and then details, and ending with reiteration of the overview and a discussion of regulation.
Concept statements in the margins throughout each chapter identify and summarize key ideas.
Summaries complement the introductory overviews and concept statements by organizing important concepts into a coherent framework at the end of each chapter.
1. The Scope of Biochemistry. 2. The Matrix of Life : Weak Interactions in an Aqueous Environment. 3. The Energetics of Life.
II. MOLECULAR ARCHITECTURE OF LIVING MATTER.
4. Nucleic Acids. 5. Introduction to Proteins : The Primary Level of Protein Structure. 6. The Three- Dimensional Structure of Proteins. 7. Protein Function and Evolution. 8. Proteins in Motion : Contractile Systems and Molecular Motors. 9. Carbohydrates. 10. Lipids, Membranes, and Cellular Transport.
III. DYNAMICS OF LIFE : CATALYSIS AND CONTROL OF BIOCHEMICAL REACTIONS.
11. Enzymes : Biological Catalysts. 12. Introduction to Metabolism.
IV. DYNAMICS OF LIFE : ENERGY, BIOSYNTHESIS, AND UTILIZATION OF PRECURSORS.
13. Carbohydrate Metabolism I : Anaerobic Processes in Generating Metabolic Energy. 14. Oxidative Processes : Citric Acid Cycle and Pentose Phosphate Pathway. 15. Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism. 16. Carbohydrate Metabolism II : Biosynthesis. 17. Photosynthesis. 18. Lipid Metabolism I : Fatty Acids, Triacylglycerols, and Lipoproteins. 19. Lipid Metabolism II : Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids. 20. Metabolism of Nitrogenous Compounds : Principles of Biosynthesis, Utilization, and Turnover. 21. Metabolism of Nitrogenous Compounds : Amino Acids, Porphyrins, and Neurotransmitters. 22. Nucleotide Metabolism. 23. Metabolic Coordination, Metabolic Control, and Signal Transduction
24. Information Copying : Replication. 25. Information Restructuring : Restriction, Repair, Recombination, Rearrangement, and Amplification. 26. Information Readout : Transcription. 27. Information Decoding : Translation. 28. Eukaryotic Genes and Their Expression.
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