Summary: Physics and engineering departments are building research programs in Biological Physics, but until now there has not been a synthesis of this dynamic field at the undergraduate level. Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of
nanotechnology. The text is built around a self-contained core geared toward undergraduate students who have had one year of calculus-based physics. Additional "Track-2" sections contain more advanced material for senior physics majors and graduate students.
Summary: Physics and engineering departments are building research programs in Biological Physics, but until now there has not been a synthesis of this dynamic field at the undergraduate level. Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of nanotechnology. The text is built around a self-contained core geared toward undergraduate students who have had one year of calculus-based physics. Additional "Track-2" sections contain more advanced material for senior physics majors and graduate students. ...show less
Edition/Copyright:04 Cover: Hardcover Publisher:W.H. Freeman Published: 08/28/2003 International: No
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Nelson, Philip : University of Pennsylvania
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I: MYSTERIES, METAPHORS, MODELS
1. What the ancients knew Sets the stage by outlining Schrodinger's "What is Life?" Reviews some background from elementary physics and chemistry.
2. What's inside cells Pictorial tour of the molecules and structures to be studied in later chapters.
II: DIFFUSION, DISSIPATION, DRIVE
3. The molecular dance Introduces basic kinetic theory. Discusses Delbruck's analysis of X-ray mutagenesis experiments and his deduction that hereditary information is carried by a long-chain molecule.
4. Random walks, friction, and diffusion Includes biological applications such as membrane permeation and the Nernst relation.
5. Life in the slow lane: The low Reynolds-number world Includes biological applications such as bacterial propulsion and vascular networks.
6. Entropy, temperature, and free energy Introduces these central concepts. Includes: "RNA folding as a two-state system" by J. Liphardt, I. Tinoco, Jr., and C. Bustamante
7. Entropic forces at work Discusses osmotic pressure, electrostatics in solution, and the hydrophobic effect.
8. Chemical forces and self-assembly Includes biological applications such as dissociation of macromolecules, electrophoresis, and self-assembly of micelles and bilayers.
III: MOLECULES, MACHINES, MECHANISMS
9. Cooperative transitions in macromolecules Discusses DNA stretching experiments, the helix-coil transition, and allosteric transitions.
10. Enzymes and molecular machines Sets up the problem of random walks on energy landscapes, then gives biological applications including enzyme kinetics and the analysis of single-molecule experiments on molecular motors.
11. Machines in membranes Discusses ion pumps, resting membrane potentials, and the chemiosmotic mechanism; then discusses recent single-molecule experiments on the ATP synthase motor. Includes: "Powering up the flagellar motor" by H. C. Berg and D. Fung
12. Nerve impulses Introduces the Hodgkin-Huxley mechanism, then analyzes recent patch-clamp experiments on single ion channels. Global list of symbols and units Numerical values Index
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