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Cell Movements : From Molecules to Motility

Cell Movements : From Molecules to Motility - 2nd edition

ISBN13: 978-0815332824

Cover of Cell Movements : From Molecules to Motility 2ND 01 (ISBN 978-0815332824)
ISBN13: 978-0815332824
ISBN10: 0815332823
Cover type:
Edition/Copyright: 2ND 01
Publisher: Garland Publishing
Published: 2001
International: No

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Cell Movements : From Molecules to Motility - 2ND 01 edition

ISBN13: 978-0815332824

Dennis Bray

ISBN13: 978-0815332824
ISBN10: 0815332823
Cover type:
Edition/Copyright: 2ND 01
Publisher: Garland Publishing

Published: 2001
International: No

Cell Movements provides senior undergraduates, graduates and professionals with an accessible and up-to-date introduction to this exciting area of biological science. The new edition of this popular book features a revised art program abundant with micrographs and line drawings, a comprehensive glossary of terms and end-of-chapter lists of unsolved questions highlighting areas ripe for future investigation.

It begins with a description of movements seen in the light microscope, giving fascinating accounts of cells that swim, crawl, glide, and display often amazingly complex and idiosyncratic behaviors. The focus then moves to the interior of the cell to describe the molecular mechanisms by which these movements are generated and controlled. The systems of proteins forming the cytoskeleton and their repertoire of dynamic reactions are first introduced, covering the polarized growth and shrinkage of protein polymers, their association into larger structures, and the directed motion of motor proteins. Then specific protein machines such as the ciliary axoneme and the bacterial flagellar motor are selected for an in-depth analysis that includes a review of what has been gleaned from recent experimental developments (such as studies of single molecules) as well as current theories and speculations. Attention is given to how cells organise their internal contents, including how cells split into two during cell division. Biophysical parameters are highlighted throughout, emphasising the importance of diffusion, viscosity, and mechanical forces in determining cellular responses. The final part of the book shows how the mechanisms and principles previously described are integrated in whole cells and organisms. It addresses complex phenomena such as the overall mechanical properties and shapes of cells, the establishment of cell polarity, and the complex movements that occur during embryonic development.

  • All chapters revised and updated. Recent developments that have been incorporated include:
  • The different families of motor proteins and their biophysical properties as revealed by single molecule measurements
  • The cellular movements that occur during the development of complex organisms
  • The mechanism of eucaryotic cell locomotion as revealed by Listeria bacteria.
  • New 'Outstanding Questions' sections at the end of each chapter outline some interesting questions for future research.
  • Completely revised and redrawn artwork program
  • New look reader-friendly text design
  • Comprehensive glossary

Author Bio

Bray, Dennis :

Dennis Bray received his Ph.D. from the Massachusetts Institute of Technology and postdoctoral training at Harvard Medical School before moving to the UK. Since then, he has been employed as a research scientist by the Medical Research Council, working at laboratories in London and in Cambridge. At various times he has served as visiting professor at the University of Otago at Washington University and at the California Institute of Technology. His research interests include neurobiology, cell biology, and the emerging field of computational cell biology. He is a co-author of the best-selling texts Molecular Biology of the Cell and Essential Cell Biology by Alberts et al.

Table of Contents

Part 1 Cell Movements in the Light Microscope

Chapter 1 Cell Swimming
Chapter 2 Migration of Cells Over Surfaces
Chapter 3 Cell Behavior
Chapter 4 The Cytoskeleton

Part 2 Molecular Basis of Cell Movements

Chapter 5 Actin Filaments
Chapter 6 Actin and Membranes
Chapter 7 Myosin
Chapter 8 Fibroblast Locomotion
Chapter 9 The Molecular Basis of Muscle Contraction
Chapter 10 Muscle Development
Chapter 11 Microtubules
Chapter 12 Organelle Transport
Chapter 13 Mitosis
Chapter 14 Cilia
Chapter 15 Centrioles and Basal Bodies
Chapter 16 Bacterial Movements

Part 3 Integration of Cell Movements

Chapter 17 Intermediate Filaments
Chapter 18 Cell Mechanics
Chapter 19 Cell Shape
Chapter 20 Cell Movements and Embryogenesis

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