Summary: This comprehensive Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new edition continues to include a thorough description of drug discovery and pharmacodynamic agents and integrates traditional principles in medicinal chemistry with pharmacology and therapeutics. The new emphasis is firmly placed on pharmaceutical care that focuses on the patient, and on the pharmacist as a therapeutic consu
ltant, rather than a chemist. Respected academic and research professionals from around the world have contributed to this exhaustive reference, yet a consistent style and format are present throughout for simplified navigation.
Summary: This comprehensive Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new edition continues to include a thorough description of drug discovery and pharmacodynamic agents and integrates traditional principles in medicinal chemistry with pharmacology and therapeutics. The new emphasis is firmly placed on pharmaceutical care that focuses on the patient, and on the pharmacist as a therapeutic consultant, rather than a chemist. Respected academic and research professionals from around the world have contributed to this exhaustive reference, yet a consistent style and format are present throughout for simplified navigation. ...show less
Edition/Copyright:6TH 08 Cover: Hardback Publisher:LeaFebiger Published: 10/01/2007 International: No
View Table of Contents
Table of Contents
Historical Perspective of Medicinal Chemistry
Part I: Principles of Drug Discovery
- Chapter 1. Drug Discovery from Natural Products - Chapter 2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity - Chapter 3. Molecular Modeling and in Silico - Chapter 4. Receptors and Drug Action - Chapter 5. Drug Discovery Through Enzyme Inhibition - Chapter 6. Pharmaceutical Biotechnology-From Nucleic Acids to Personalized Medicine - Chapter 7. Peptide and Protein Drugs - Chapter 8. Antisense Therapeutic Agents - Chapter 9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics - Chapter 10. Drug Metabolism - Chapter 11. Drug Regulation: An Overview
Part II: Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors - Overview of Drug Receptors: A Perspective - Chapter 12. Drugs Affecting Cholinergic Neurotransmission - Chapter 13. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission - Chapter 14. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission - Chapter 15. Amino Acid Neurotransmitters in the Central Nervous System - Chapter 16. Inhibitors of Nerve Conduction: Local Anesthetics - Chapter 17. Phosphodiesterase Inhibitors
Part III: Pharmacodynamic Agents
Section 1: Drugs Affecting Central Nervous System - Chapter 18. General Anesthetics - Chapter 19. Sedative-Hypnotics - Chapter 20. Antiseizure Agents - Chapter 21. Antidepressants - Chapter 22. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents - Chapter 23. Hallucinogens, Stimulants and Related Drugs of Abuse - Chapter 24. Opioid Analgesics - Chapter 25. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents
Section 2: Drugs Affecting the Cardiovascular System - Chapter 26. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs - Chapter 27. Diuretics - Chapter 28. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers - Chapter 29. Central and Peripheral Sympatholytics and Vasodilators - Chapter 30. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis - Chapter 31. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders
Section 3: Drugs Affecting the Hormonal Systems - Chapter 32. Insulin and Drugs Used for the Treatment of Diabetes - Chapter 33. Adrenocorticoids - Chapter 34. Thyroid Function and Thyroid Drugs - Chapter 35. Calcium Homeostasis - Section 4: Drugs Affecting the Immune Systems Chapter 36. Nonsteroidal Anti-Inflammatory Drugs - Chapter 37. Antihistamines and Related Antiallergic and Antiulcer Agents
Section 5: Chemotherapeutic Agents - Chapter 38. Antibiotics and Antimicrobial Agents - Chapter 39. Antiparasitic Agents - Chapter 40. Antifungal Agents - Chapter 41. Antimycobacterial Agents - Chapter 42. Cancer and Chemotherapy - Chapter 43. Antiviral Agents and Protease Inhibitors
Part IV: Disease State Management - Chapter 44. Asthma and Chronic Obstructive Pulmonary Disease - Chapter 45. Men' Health - Chapter 46. Women's Health
Appendix A: pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases
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