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From Neuron to Brain -Text Only

From Neuron to Brain -Text Only - 5th edition

ISBN13: 978-0878936090

Cover of From Neuron to Brain -Text Only 5TH 12 (ISBN 978-0878936090)
ISBN13: 978-0878936090
ISBN10: 0878936092
Cover type: Hardback
Edition/Copyright: 5TH 12
Publisher: Sinauer Associates, Inc.
Published: 2012
International: No
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From Neuron to Brain -Text Only - 5TH 12 edition

ISBN13: 978-0878936090

John G. Nicholls, A. Robert Martin and Bruce G. Wallace

ISBN13: 978-0878936090
ISBN10: 0878936092
Cover type: Hardback
Edition/Copyright: 5TH 12
Publisher: Sinauer Associates, Inc.

Published: 2012
International: No
Summary

The entirely rewritten Fifth Edition of From Neuron to Brain describes how nerve cells go about their business of transmitting signals, how the signals are put together, and how, out of this integration, higher functions emerge. This exciting new edition begins with the anatomy and physiology of the visual system.

Table of Contents

I. Introduction 1. Principles of Signaling and Organization Organization of the Retina Signaling in Nerve Cells Cellular and Molecular Biology of Neurons Signals for Development of the Nervous System Regeneration of the Nervous System after Injury II. Signaling in the Nervous System Membrane Proteins and Their Function 2. Ion Channels and Signaling Properties of Ion Channels Measurement of Single-Channel Currents BOX 2.1. Measuring Channel Conductance 3. Structure of Ion Channels The Nicotinic Acetylcholine Receptor A Receptor Superfamily Voltage-Activated Channels Other Channels Diversity of Subunits Conclusion BOX 3.1. Cloning Receptors and Channels BOX 3.2. Classification of Amino Acids BOX 3.3. Expression of Receptors and Channels in Xenopus Oocytes 4. Transport across Cell Membranes The Sodium-Potassium Exchange Pump Calcium Pumps Sodium-Calcium Exchange Chloride Transport Transport of Neurotransmitters Molecular Structure of Transporters Significance of Transport Mechanisms Properties of Neurons and Glia 5. Ionic Basis of the Resting Potential A Model Cell Membrane Potentials in Squid Axons Changes in Membrane Potential 6. Ionic Basis of the Action Potential Sodium and Potassium Currents Voltage Clamp Experiments The Role of Calcium in Excitation BOX 6.1. The Voltage Clamp 7. Neurons as Conductors of Electricity Passive Electrical Properties of Nerve and Muscle Membranes Propagation of Action Potentials Conduction in Dendrites Pathways for Current Flow between Cells BOX 7.1. Electrotonic Potentials and the Membrane Time Constant BOX 7.2. Classification of Nerve Fibers in Vertebrates BOX 7.3. Stimulating and Recording with External Electrodes BOX 7.4. Current Flow between Cells 8. Properties and Functions of Neuroglial Cells Physiological Properties of Neuroglial Cell Membranes Functions of Neuroglial Cells Effects of Neuronal Activity on Glial Cells Glial Cells and the Blood-Brain Barrier Glial Cells and Immune Responses of the CNS BOX 8.1. The Blood-Brain Barrier Communication between Excitable Cells 9. Principles of Direct Synaptic Transmission Nerve Cells and Synaptic Connections Electrical Synaptic Transmission Chemical Synaptic Transmission Direct Synaptic Inhibition BOX 9.1. Electrical Model of the Motor End Plate 10. Indirect Mechanisms of Synaptic Transmission Metabotropic Receptors and G Proteins Direct Modulation of Channel Function by G Proteins G Protein Activation of Cytoplasmic Second Messenger Systems Calcium as an Intracellular Second Messenger Prolonged Time Course of Indirect Transmitter Action BOX 10.1. Identifying Responses Mediated by G Proteins BOX 10.2. Cyclic AMP as a Second Messenger BOX 10.3. Diacylglycerol and IP3 as Second Messengers BOX 10.4. Formation and Metabolism of Arachidonic Acid 11. Transmitter Release Characteristics of Transmitter Release Quantal Release Vesicle Hypothesis of Transmitter Release 12. Synaptic Plasticity Short-Term Changes in Signaling Long-Term Changes in Signaling 13. Cellular and Molecular Biochemistry of Synaptic Transmission Neurotransmitters Neurotransmitter Synthesis Storage of Transmitters in Synaptic Vesicles Axonal Transport Transmitter Release and Vesicle Recycling Transmitter Receptor Localization Removal of Transmitters from the Synaptic Cleft BOX 13.1. The SNARE Hypothesis 14. Neurotransmitters in the Central Nervous System Mapping Transmitter Distribution Peptide Transmitters in the CNS Regulation of Central Nervous System Function by Biogenic Amines BOX 14.1. Molecular Methods and CNS Transmitters III. Integrative Mechanisms Circuits Mediating Stereotyped Behavior 15. Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees From Neurons to Behavior and Vice Versa Integration by Individual Neurons in the CNS of the Leech Navigation by Ants and Bees Why Should One Work on Invertebrate Nervous Systems? 16 Autonomic Nervous System Functions under Involuntary Control Synaptic Transmission by Postganglionic Axons BOX 16.1. The Path to Understanding Sympathetic Mechanisms Acquisition and Analysis of Sensory Information 17. Transduction of Mechanical and Chemical Stimuli Stimulus Coding by Mechanoreceptors Transduction of Mechanical Stimuli Olfaction Mechanisms of Taste (Gustation) Transduction of Nociceptive and Thermal Stimuli BOX 17.1. Sensory Epithelia of the Inner Ear 18. Processing of Somatosensory and Auditory Signals The Somatosensory System: Tactile Recognition The Auditory System: Encoding Sound Frequency BOX 18.1. Brodmann's Areas The Visual System 19. Transduction and Signaling in the Retina The Eye The Retina Visual Pigments Transduction by Photoreceptors Transmission from Photoreceptors to Bipolar Cells Receptive Fields of Ganglion Cells BOX 19.1. Adaptation of Photoreceptors 20. Analysis of Form in Primary Visual Cortex The Lateral Geniculate Nucleus Cytoarchitecture of the Cortex Strategies for Exploring the Cortex 21. Functional Architecture of the Visual Cortex Ocular Dominance Slabs The Integration of Visual Information Where Do We Go from Here? BOX 21.1. Color Constancy BOX 21.2. Corpus Callosum Initiation and Control of Movement 22. Cellular Mechanisms of Motor Control The Motor Unit Spinal Reflexes Generation of Coordinated Movement Motor Cortex and the Execution of Voluntary Movement The Cerebellum The Basal Ganglia BOX 22.1.Extracellular Recording of Motor Activity IV. Development of the Nervous System 23. Development of the Nervous System Early Neural Morphogenesis Regional Specification of Neural Tissue Determination of Neuronal and Glial Cell Identity Axon Outgrowth Axon Guidance Target Innervation Synapse Formation Growth Factors and Survival of Neurons Competitive Interactions during Development General Considerations of Neural Specificity BOX 23.1. Discovery of Nerve Growth Factor 24. Denervation and Regeneration of Synaptic Connections Changes in Axotomized Neurons and the Surrounding Glial Cells Effects of Denervation on Postsynaptic Cells Regeneration in the Vertebrate Peripheral Nervous System Role of Basal Lamina at Regenerating Synapses Regeneration in the Mammalian CNS 25. Critical Periods in Visual and Auditory Systems The Visual System in Newly Born Monkeys and Kittens Effects of Abnormal Experience in Early Life Requirements for Maintenance of Functioning Connections in the Visual System Cellular and Molecular Mechanisms of Deprivation Changes Critical Periods in the Auditory System Critical Periods for Higher Functions V. Conclusion 26. Open Questions Appendix A: Current Flow in Electrical Circuits Appendix B: Metabolic Pathways for the Synthesis and Inactivation of Low-Molecular-Weight Transmitters Appendix C: Structures and Pathways of the Brain Bibliography Index

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Cover of From Neuron to Brain 4th edition

From Neuron to Brain - 4th edition

ISBN13: 978-0878934393
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