Summary: Fundamental Concepts of Bioinformatics is the first textbook co-authored by a biologist and computer scientist that is specifically designed to make bioinformatics accessible to undergraduates and prepare them for more advanced work. Students learn what programs are available for analyzing data, how to understand the basic algorithms that underlie these programs, what bioinformatic research is like, and other basic concepts. Information flows easily from one topic to
the next, with enough detail to support the major concepts without overwhelming students. Problems at the end of each chapter use real data to help students apply what they have learned so they know how to critically evaluate results from both a statistical and biological point of view.
Summary: Fundamental Concepts of Bioinformatics is the first textbook co-authored by a biologist and computer scientist that is specifically designed to make bioinformatics accessible to undergraduates and prepare them for more advanced work. Students learn what programs are available for analyzing data, how to understand the basic algorithms that underlie these programs, what bioinformatic research is like, and other basic concepts. Information flows easily from one topic to the next, with enough detail to support the major concepts without overwhelming students. Problems at the end of each chapter use real data to help students apply what they have learned so they know how to critically evaluate results from both a statistical and biological point of view. ...show less
Edition/Copyright:03 Cover: Paperback Publisher:Benjamin-Cummings Publishing Co. Published: 09/12/2002 International: No
View Table of Contents
I. MOLECULAR BIOLOGY AND BIOLOGICAL CHEMISTRY.
The genetic material.
Nucleotides. Orientation. Base pairing. The central dogma of molecular biology.
Gene structure and information content.
Promoter sequences. The genetic code. Open reading frames. Introns and exons.
Protein structure and function.
Primary structure. Secondary, tertiary and quaternary structure.
The nature of chemical bonds.
Anatomy of an atom. Valence. Electronegativity. Hydrophilicity and hydrophobicity.
Molecular biology tools.
Restriction enzymes. Gel electrophoresis. Blotting, hybridization and microarrays. Cloning. Polymerase chain reaction (PCR). DNA sequencing.
Genomic information content.
C value paradox. Reassociation kinetics.
II. DATA SEARCHES AND PAIRWISE ALIGNMENTS.
Dot plots. Simple alignments. Scoring. Gaps.
Simple gap penalties. Origination and length penalties.
Scoring matrices. Dynamic programming: The Needleman and Wunsch algorithm. Local and global alignments.
Global and Semi-global alignments. The Smith-Waterman algorithm.
BLAST and its relatives. Other algorithms.
Multiple sequence alignments.
III. SUBSTITUTION PATTERNS.
Patterns of substitutions within genes.
Mutation rates. Functional constraint. Synonymous vs. nonsynonymous changes. Indels and psuedogenes. Substitutions vs. mutations. Fixation.
Estimating substitution numbers.
Jukes/Cantor model. Transitions and transversions. Kimura's two-parameter model. Models with even more parameters. Substitutions between protein sequences.
Variations in substitution rates between genes. Molecular clocks.
Relative rate tests. Causes of rate variation in lineages.
Evolution in organelles.
IV. DISTANCE-BASED METHODS OF PHYLOGENETICS.
History of molecular phylogenetics. Advantages to molecular phylogenies. Phylogenetic trees.
Terminology of tree reconstruction. Rooted and unrooted trees. Gene vs. species trees. Character and distance data.
Barnes & Noble.com Various Shipping Locations, USA
Brand new, ships from the closest shipping location to your shipping address!
$3.98 +$3.99 s/h
Seattle Goodwill WA Seattle, WA
2002 Paperback Fair
$9.99 +$3.99 s/h
HPB-Westport Kansas City, MO
2002 Paperback Good Connecting readers with great books since 1972. Used books may not include companion materials, some shelf wear, may contain highlighting/notes, and may not include cd-rom or ac...show morecess codes. Customer service is our top priority! ...show less
$18.09 +$3.99 s/h
newrecycleabook centerville, OH
0805346333 Book is in VERY GOOD condition - may show minor signs of use, may NOT contain supplemental materials - Free tracking information on all orders!
$39.95 +$3.99 s/h
omgtextbooks Pueblo West, CO
San Francisco, CA 2002 Trade paperback Annotated. Good. Trade paperback (US). Glued binding. 320 p. Genetics Place.
$55.37 +$3.99 s/h
One Planet Books Columbia, MO
Ships same day or next business day! UPS expedited shipping available (Priority Mail for AK/HI/APO/PO Boxes). Used sticker & some writing and/or highlighting. Used books may not include working access...show more code or dust jacket ...show less
$79.10 +$3.99 s/h
Textbookcenter.com Columbia, MO
Ships same day or next business day via UPS (Priority Mail for AK/HI/APO/PO Boxes)! Used sticker and some writing and/or highlighting. Used books may not include working access code or dust jacket.
$93.11 +$3.99 s/h
bargainforce Chicago, IL
No comments from the seller
$118.65 +$3.99 s/h
Textbookcenter.com Columbia, MO
Ships same day or next business day! UPS(AK/HI Priority Mail)/ NEW book
$135.33 +$3.99 s/h
GreatBookPrices Westminster, MD
Brand New, Perfect Condition, Please allow 4-14 business days for delivery. 100% Money Back Guarantee, Over 1,000,000 customers served.
$136.69 +$3.99 s/h
GreatBookPrices Westminster, MD
Used, Acceptable Condition, may show signs of wear and previous use. Please allow 4-14 business days for delivery. 100% Money Back Guarantee, Over 1,000,000 customers served.
Free Shipping Get Free Shipping on orders over $25 (not including Rental and Marketplace). Order arrives in 5-10 business days.
Need it faster? We offer fast, flat-rate expedited shipping options.
Not the right book for you? We'll gladly take it back within 30 days.
To return an eTextbook:
Your eTextbook is non-returnable once it's been activated. You must contact us about returning your eTextbook before you activate it.
Returns are accepted within 30 days of the purchase date on your order confirmation.
This book qualifies for guaranteed cash back! Buy it now for , then:
Sell it back by:
Guaranteed cash back:
Cost of this book after cash back:
Take advantage of Guaranteed Cash Back. Send your book to us in good condition before the end of the buyback period, we'll send YOU a check, and you'll pay less for your textbooks!
If you find this book for less on Amazon.com (direct from Amazon, not marketplace sellers), we'll match it.
In our warehouse, waiting to ship directly to you.
We hand-inspect every used textbook to make sure it's in good condition.
Buy it now. Sell it later!
Sell this textbook for cash!
When you're done with this book, sell it back to Textbooks.com. In addition to the best possible buyback price, you'll get an extra 10% cash back just for being a customer.
We buy good-condition used textbooks year 'round, 24/7. No matter where you bought it, Textbooks.com will buy your textbooks for the most cash.
We hand-inspect every one of our used textbooks to ensure good condition.
Our used textbooks do NOT have:
Missing or torn pages
Missing or torn cover
Torn or damaged binding
A broken spine
This textbook has never been used.
Due to the size of eTextbooks, a high-speed internet connection (cable modem, DSL, LAN) is required for download stability and speed. Your connection can be wired or wireless.
Being online is not required for reading an eTextbook after successfully downloading it. You must only be connected to the Internet duringthe download process.
XP or Windows 7 (32 or 64 running in 32 bit mode), or Mac OS 10.6 or above
At least 512 MB RAM, 600 mHZ processor, and 40 MB of hard drive space (75MB for Mac OS)
What is the Marketplace? It's another way for you to get the right price on the books you need. We approved every Marketplace vendor to sell their books on Textbooks.com, so you know they're all reliable.
What are Marketplace shipping options? Marketplace items do not qualify for free shipping. When ordering from the Marketplace, please specify whether you want the seller to send your book Standard ($3.99/item) or Express ($6.99/item). To get free shipping over $25, just order directly from Textbooks.com instead of through the Marketplace.
FREE UPS 2nd Day Air Terms
Rental and Marketplace items are excluded. Offer is valid from 1/21/2013 12:00PM to 1/23/2013 11:59AM CST. Your order must be placed by 12 Noon CST to be processed on the same day. Minimum order value is $100.00 excluding Rental and Marketplace items. To redeem this offer, select "FREE UPS 2ND DAY AIR" at checkout. Offer not is not valid on previous orders.