Fundamentals Of Biochemistry - 4th edition

Donald Voet received a B.S. in Chemistry from the California Institute of Technology, a Ph.D. in Chemistry from Harvard University with William Lipscomb, and did postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoctoral research, Don took up a faculty position in the Chemistry Department at the University of Pennsylvania where, for the past 38 years, he has taught a variety of Biochemistry courses as well as general Chemistry. His major area of research is the X-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, The University of California at San Diego, and the Weizmann Institute of Science in Israel. Together with Judith G. Voet, he is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. He is a member of the Education Committee of the International Union of Biochemistry and Molecular Biology. His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing Biochemistry textbooks.

Judith ("Judy") Voet received her B.S. in Chemistry from Antioch College and her Ph.D. in Biochemistry from Brandeis University with Robert H. Abeles. She has done postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Her main area of research involves enzyme reaction mechanisms and inhibition. She taught Biochemistry at the University of Delaware before moving to Swarthmore College. She taught there for 26 years, reaching the position of James H. Hammons Professor of Chemistry and Biochemistry before going on "permanent sabbatical leave." She has been a visiting scholar at Oxford University, University of California, San Diego, University of Pennsylvania, and the Weizmann Institute of Science, Israel. She is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. She has been a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology as well as the Education Committee of the International Union of Biochemistry and Molecular Biology. Her hobbies include hiking, backpacking, scuba diving, and tap dancing.

Charlotte Pratt received her B.S. in Biology from the University of Notre Dame and her Ph.D. in Biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that Biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral researching the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches at Seattle Pacific University. In addition to working as an editor of several Biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry.

Table of Contents

PART I INTRODUCTION
1 Introduction to the Chemistry of Life
2 Water

PART II BIOMOLECULES
3 Nucleotides, Nucleic Acids, and Genetic Information
4 Amino Acids
5 Proteins: Primary Structure
6 Proteins: Three-Dimensional Structure
7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
8 Carbohydrates
9 Lipids and Biological Membranes
10 Membrane Transport

12 Enzyme Kinetics, Inhibition, and Control
13 Biochemical Signaling

PART IV METABOLISM
14 Introduction to Metabolism
15 Glucose Catabolism
16 Glycogen Metabolism and Gluconeogenesis
17 Citric Acid Cycle
18 Electron Transport and Oxidative Phosphorylation
19 Photosynthesis
20 Lipid Metabolism
21 Amino Acid Metabolism
22 Mammalian Fuel Metabolism: Integration and Regulation

PART V GENE EXPRESSION AND REPLICATION
23 Nucleotide Metabolism
24 Nucleic Acid Structure
25 DNA Replication, Repair, and Recombination
26 Transcription and RNA Processing
27 Protein Synthesis
28 Regulation of Gene Expression