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Fundamentals of Biochemistry / With CD-ROM

Fundamentals of Biochemistry / With CD-ROM - 99 edition

ISBN13: 978-0471586500

Cover of Fundamentals of Biochemistry / With CD-ROM 99 (ISBN 978-0471586500)
ISBN13: 978-0471586500
ISBN10: 0471586501
Cover type:
Edition/Copyright: 99
Publisher: John Wiley & Sons, Inc.
Published: 1999
International: No

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Fundamentals of Biochemistry / With CD-ROM - 99 edition

ISBN13: 978-0471586500

Donald Voet, Judith G. Voet and Charlotte W. Pratt

ISBN13: 978-0471586500
ISBN10: 0471586501
Cover type:
Edition/Copyright: 99
Publisher: John Wiley & Sons, Inc.

Published: 1999
International: No
Summary

This text uses a more brief and qualitative approach to present biochemistry with chemical rigor, focusing on the structures of biomolecules, chemical mechanisms, and evolutionary relationships. It is written to impart a sense of intellectual history of biochemistry, an understanding of the tools and approaches used to solve biochemical puzzles, and a hint of the excitement that accompanies new discoveries.

Table of Contents

LIFE.

The Origin of Life.
Cellular Architecture.
Organismal Evolution.
Thermodynamics.

WATER.

Physical Properties of Water.
Chemical Properties of Water.

NUCLEOTIDES AND NUCLEIC ACIDS.

Nucleotide Structure and Function.
Nucleic Acid Structure.
Overview of Nucleic Acid Function.
Nucleic Acid Sequencing.
Recombinant DNA Technology.

AMINO ACIDS.

Amino Acid Structure.
Stereochemistry.
Nonstandard Amino Acids.

PROTEINS: PRIMARY STRUCTURE.

Polypeptide Diversity.
Protein Purification.
Protein Sequencing.
Protein Evolution.

PROTEINS: THREE-DIMENSIONAL STRUCTURE.

Secondary Structure.
Tertiary Structure.
Quaternary Structure and Symmetry.
Protein Folding and Stability.

PROTEIN FUNCTION.

Myoglobin.
Hemoglobin.
Myosin and Actin.
Antibodies.

CARBOHYDRATES.

Monosaccharides.
Polysaccharides.
Glycoproteins.

LIPIDS.

Lipid Classification.
Lipid Bilayers.

BIOLOGICAL MEMBRANES.

Membrane Proteins.
Membrane Structure and Assembly.
Lipoproteins and Receptor-Mediated Endocytosis.
Transport Across Membranes.

ENZYMATIC CATALYSIS.

General Properties of Enzymes.
Activation Energy and the Reaction Coordinate.
Catalytic Mechanisms.
Lysozyme.
Serine Proteases.

ENZYME KINETICS, INHIBITION, AND REGULATION.

Reaction Kinetics.
Enzyme Inhibition.
Regulation of Enzyme Activity.

INTRODUCTION TO METABOLISM.

Overview of Metabloism.
"High-Energy" Compounds.
Oxidation--Reduction Reactions.
Experimental Approaches to the Study of Metabolism.

GLUCOSE CATABOLISM.

Overview of Glycolysis.
The Reactions of Glycolysis.
Fermentation: The Anaerobic Fate of Pyruvate.
Control of Glycolysis.
Metabolism of Hexoses Other Than Glucose.
The Pentose Phosphate Pathway.

GLYCOGEN METABOLISM AND GLUCONEOGENESIS.

Glycogen Breakdown.
Glycogen Synthesis.
Control of Glycogen Metabolism.
Gluconeogenesis.
Other Carbohydrate Biosynthetic Pathways.

CITRIC ACID CYCLE.

Overview of the Citric Acid Cycle.
Synthesis of Acetyl-Coenzyme A. Enzymes of the Citric Acid Cycle.
Regulation of the Citric Acid Cycle.
Reactions Related to the Citric Acid Cycle.

ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION.

The Mitochondrion.
Electron Transport.
Oxidative Phosphorylation.
Control of ATP Production.
Physiological Implications of Aerobic Metabolism.

PHOTOSYNTHESIS.

Chloroplasts.
The Light Reactions.
The Dark Reactions.

LIPID METABOLISM.

Lipid Digestion, Absorption, and Transport.
Fatty Acid Oxidation.
Ketone Bodies.
Fatty Acid Biosynthesis.
Regulation of Fatty Acid Metabolism.
Membrane Lipid Synthesis.
Cholesterol Metabolism.

AMINO ACID METABOLISM.

Protein Degradation.
Amino Acid Deamination.
The Urea Cycle.
Breakdown of Amino Acids.
Amino Acid Biosynthesis.
Other Products of Amino Acid Metabolism.
Nitrogen Fixation.

MAMMALIAN FUEL METABOLISM: INTEGRATION AND REGULATION.

Organ Specialization.
Interorgan Metabolisc Pathways.
Mechanisms of Hormone Action: Signal Transduction.
Disturbances in Fuel Metabolism.

NUCLEOTIDE METABOLISM.

Synthesis of Purine Ribonucleotides.
Synthesis of Pyrimidine Nucleotides.
Formation of Deoxyribonucleotides.
Nucleotide Degradation.

NUCLEIC ACID STRUCTURE.

The DNA Helix.
Forces Stabilizing Nucleic Acid Structures.
Fractionation of Nucleic Acids.
DNA--Protein Interactions.
Eukaryotic Chromosome Structure.

DNA REPLICATION, REPAIR, AND RECOMBINATION.

Overview of DNA Replication.
Prokaryotic DNA Replication.
Eukaryotic DNA Replication.
Mutation.
DNA Repair.
Recombination.

TRANSCRIPTION AND RNA PROCESSING.

RNA Polymerase.
Transcription in Eukaryotes.
Posttranscriptional Processing.

TRANSLATION.

The Genetic Code.
Transfer RNA and Its Aminoacylation.
Ribosomes.
Polypeptide.

REGULATION OF GENE EXPRESSION.

Genome Organization.
Regulation of Prokaryotic Gene Expression.
Regulation of Eukaryotic Gene Expression.

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