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Summary: This text uses a more brief and qualitative approach to present biochemistry with chemical rigor, focusing on the structures of biomolecules, chemical mechanisms, and evolutionary relationships. It is written to impart a sense of intellectual history of biochemistry, an understanding of the tools and approaches used to solve biochemical puzzles, and a hint of the excitement that accompanies new discoveries.Edition/Copyright: 99
The Origin of Life.
Physical Properties of Water.
Chemical Properties of Water.
NUCLEOTIDES AND NUCLEIC ACIDS.
Nucleotide Structure and Function.
Nucleic Acid Structure.
Overview of Nucleic Acid Function.
Nucleic Acid Sequencing.
Recombinant DNA Technology.
Amino Acid Structure.
Nonstandard Amino Acids.
PROTEINS: PRIMARY STRUCTURE.
PROTEINS: THREE-DIMENSIONAL STRUCTURE.
Quaternary Structure and Symmetry.
Protein Folding and Stability.
Myosin and Actin.
Membrane Structure and Assembly.
Lipoproteins and Receptor-Mediated Endocytosis.
Transport Across Membranes.
General Properties of Enzymes.
Activation Energy and the Reaction Coordinate.
ENZYME KINETICS, INHIBITION, AND REGULATION.
Regulation of Enzyme Activity.
INTRODUCTION TO METABOLISM.
Overview of Metabloism.
Experimental Approaches to the Study of Metabolism.
Overview of Glycolysis.
The Reactions of Glycolysis.
Fermentation: The Anaerobic Fate of Pyruvate.
Control of Glycolysis.
Metabolism of Hexoses Other Than Glucose.
The Pentose Phosphate Pathway.
GLYCOGEN METABOLISM AND GLUCONEOGENESIS.
Control of Glycogen Metabolism.
Other Carbohydrate Biosynthetic Pathways.
CITRIC ACID CYCLE.
Overview of the Citric Acid Cycle.
Synthesis of Acetyl-Coenzyme A. Enzymes of the Citric Acid Cycle.
Regulation of the Citric Acid Cycle.
Reactions Related to the Citric Acid Cycle.
ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION.
Control of ATP Production.
Physiological Implications of Aerobic Metabolism.
The Light Reactions.
The Dark Reactions.
Lipid Digestion, Absorption, and Transport.
Fatty Acid Oxidation.
Fatty Acid Biosynthesis.
Regulation of Fatty Acid Metabolism.
Membrane Lipid Synthesis.
AMINO ACID METABOLISM.
Amino Acid Deamination.
The Urea Cycle.
Breakdown of Amino Acids.
Amino Acid Biosynthesis.
Other Products of Amino Acid Metabolism.
MAMMALIAN FUEL METABOLISM: INTEGRATION AND REGULATION.
Interorgan Metabolisc Pathways.
Mechanisms of Hormone Action: Signal Transduction.
Disturbances in Fuel Metabolism.
Synthesis of Purine Ribonucleotides.
Synthesis of Pyrimidine Nucleotides.
Formation of Deoxyribonucleotides.
NUCLEIC ACID STRUCTURE.
The DNA Helix.
Forces Stabilizing Nucleic Acid Structures.
Fractionation of Nucleic Acids.
Eukaryotic Chromosome Structure.
DNA REPLICATION, REPAIR, AND RECOMBINATION.
Overview of DNA Replication.
Prokaryotic DNA Replication.
Eukaryotic DNA Replication.
TRANSCRIPTION AND RNA PROCESSING.
Transcription in Eukaryotes.
The Genetic Code.
Transfer RNA and Its Aminoacylation.
REGULATION OF GENE EXPRESSION.
Regulation of Prokaryotic Gene Expression.
Regulation of Eukaryotic Gene Expression.
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