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Fundamentals of Genetic Epidemiology

Fundamentals of Genetic Epidemiology - 93 edition

ISBN13: 978-0195052886

Cover of Fundamentals of Genetic Epidemiology 93 (ISBN 978-0195052886)
ISBN13: 978-0195052886
ISBN10: 0195052889
Cover type:
Edition/Copyright: 93
Publisher: Oxford University Press
Published: 1993
International: No

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Fundamentals of Genetic Epidemiology - 93 edition

ISBN13: 978-0195052886

Muin J. Khoury

ISBN13: 978-0195052886
ISBN10: 0195052889
Cover type:
Edition/Copyright: 93
Publisher: Oxford University Press

Published: 1993
International: No
Summary

With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society.

Author Bio

Khoury, Muin J. : Centers for Disease Control


Beaty, Terri H. : Johns Hopkins University


Cohen, Bernice H. : Johns Hopkins University



Table of Contents

1. Scope and Strategies of Genetic Epidemiology
2. Fundamental Genetic Concepts and Approaches
3. Fundamental Epidemiologic Concepts and Approaches
4. Study of Genetic Traits
5. Study of Genetic Factors in Disease
6. Epidemiologic Approaches to Familial Aggregation
7. Genetic Approaches to Familial Aggregation: Heritability
8. Genetic Approaches to Familial Aggregation: Segregation Analysis
9. Genetic Approaches to Familial Aggregation: Linkage Analysis
10. Applications of Genetic Epidemiology in Medicine and Public Health

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