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Genetic Switch : Phage and Higher Organisms

Genetic Switch : Phage and Higher Organisms - 2nd edition

ISBN13: 978-0865422094

Cover of Genetic Switch : Phage and Higher Organisms 2ND 92 (ISBN 978-0865422094)
ISBN13: 978-0865422094
ISBN10: 0865422095
Cover type:
Edition/Copyright: 2ND 92
Publisher: Blackwell Science, Inc.
Published: 1992
International: No

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Genetic Switch : Phage and Higher Organisms - 2ND 92 edition

ISBN13: 978-0865422094

Mark Ptashne

ISBN13: 978-0865422094
ISBN10: 0865422095
Cover type:
Edition/Copyright: 2ND 92
Publisher: Blackwell Science, Inc.

Published: 1992
International: No
Summary

A Genetic Switch is concerned with how the lambda virus uses its genes to direct its growth. All cells of a given organism inherit the same set of DNA. However, as a higher organism develops from a fertilized egg, a variety of different cell types emerges. Underlying the process of development is the selective use of genes - the phenomenon known as gene regulation. Thus, at any given time, each cell uses only a subset of its genes to direct production of other molecules, and those genes that are expressed are `on', and those not expressed are `off'. The first edition of A Genetic Switch was eagerly awaited and enthusiastically received. Ptashne's incisive experiments on gene regulation in phage lambda pioneered research into one of the key questions confronting molecular biology - what mechanisms control the turning on and off of genes? The answer (for lambda) is beautifully expounded in A Genetic Switch. In this second edition, the author looks beyond lambda to consider gene regulation in higher organisms. Two completely new chapters investigate how far regulation in eukaryotes can be described in terms of the lambda switch and fully and coherently explain what elaborations are necessary for more complex programs of gene expression.

  • The author is a leading authority in his field with 20 years experience in the study of gene regulation in lambda
  • Two completely new chapters investigate gene regulation in eukaryotes
  • Ptashne's hallmark is his ability to explain the seemingly complicated in a clear, logical and coherent style

Table of Contents

The Master Elements of Control

Components of the Switch
the Action of Repressor and Cro
Induction - Flipping the Switch
Cooperativity - Switch Stability and Sensitivity
The Effect of Autoregulation
Other Cases


Protein-DNA Interactions and Gene Control

The Operator; Repressor Cro
Amino Acid-Base Pair Interactions
The Promoter
Gene Control


Control Circuits - Setting the Switch

A Brief Overview of Lambda Growth
Control of Transcription
The Decision
Control of Integration and Excision
Other Phages
The SOS Response
Pathways and Cell Development


How do we Know - The Key Experiments

The Repressor Idea
The Repressor Problem in the Early 1960s
Repressor Isolation and DNA-Binding
Making More Repressor
The Claims of Chapters One and Two

Eukaryotic Gene Regulation - An Overview

Eukaryotic Genes and their Polymerases
AIntroduction
activation
Repression
Cooperativity
Regulators Assembled for Non-identical Components
Speculations on Development and Evolution
Caveats


Eukaryotic Gene Regulation - Experiments and Examples

Background
Two Functions of an Activator: DNA Binding and Activation
DNA Binding Structures
Activating Regions
Action at a Distance- Looping
Activation In Vivo and In Vitro
Squelching; Repression
Regulators Assembled from Non-identical Components
More Cooperativity
The Case of Eve

Conclusion
Appendix One
Designing an Efficient DNA-binding Protein

Appendix Two
Strong and Weak Interactions

Appendix Three
Control of Transcription in Eukaryotes and Prokaryotes - a common mechanism

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