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Genetic Switch : Phage and Higher Organisms - 2nd edition

Genetic Switch : Phage and Higher Organisms (ISBN10: 0865422095; ISBN13: 9780865422094)
ISBN13: 978-0865422094
ISBN10: 0865422095

Summary: A Genetic Switch is concerned with how the lambda virus uses its genes to direct its growth. All cells of a given organism inherit the same set of DNA. However, as a higher organism develops from a fertilized egg, a variety of different cell types emerges. Underlying the process of development is the selective use of genes - the phenomenon known as gene regulation. Thus, at any given time, each cell uses only a subset of its genes to direct production of other
molecules, and those genes that are expressed are `on', and those not expressed are `off'. The first edition of A Genetic Switch was eagerly awaited and enthusiastically received. Ptashne's incisive experiments on gene regulation in phage lambda pioneered research into one of the key questions confronting molecular biology - what mechanisms control the turning on and off of genes? The answer (for lambda) is beautifully expounded in A Genetic Switch. In this second edition, the author looks beyond lambda to consider gene regulation in higher organisms. Two completely new chapters investigate how far regulation in eukaryotes can be described in terms of the lambda switch and fully and coherently explain what elaborations are necessary for more complex programs of gene expression.
  • The author is a leading authority in his field with 20 years experience in the study of gene regulation in lambda
  • Two completely new chapters investigate gene regulation in eukaryotes
  • Ptashne's hallmark is his ability to explain the seemingly complicated in a clear, logical and coherent style
...show more
Summary: A Genetic Switch is concerned with how the lambda virus uses its genes to direct its growth. All cells of a given organism inherit the same set of DNA. However, as a higher organism develops from a fertilized egg, a variety of different cell types emerges. Underlying the process of development is the selective use of genes - the phenomenon known as gene regulation. Thus, at any given time, each cell uses only a subset of its genes to direct production of other molecules, and those genes that are expressed are `on', and those not expressed are `off'. The first edition of A Genetic Switch was eagerly awaited and enthusiastically received. Ptashne's incisive experiments on gene regulation in phage lambda pioneered research into one of the key questions confronting molecular biology - what mechanisms control the turning on and off of genes? The answer (for lambda) is beautifully expounded in A Genetic Switch. In this second edition, the author looks beyond lambda to consider gene regulation in higher organisms. Two completely new chapters investigate how far regulation in eukaryotes can be described in terms of the lambda switch and fully and coherently explain what elaborations are necessary for more complex programs of gene expression.
  • The author is a leading authority in his field with 20 years experience in the study of gene regulation in lambda
  • Two completely new chapters investigate gene regulation in eukaryotes
  • Ptashne's hallmark is his ability to explain the seemingly complicated in a clear, logical and coherent style
...show less

Edition/Copyright: 2ND 92
Cover:
Publisher: Blackwell Science, Inc.
Year Published: 1992
International: No

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