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How the Human Genome Works

How the Human Genome Works - 04 edition

ISBN13: 978-0763723842

Cover of How the Human Genome Works 04 (ISBN 978-0763723842)
ISBN13: 978-0763723842
ISBN10: 0763723843
Cover type: Print On Demand
Edition/Copyright: 04
Publisher: Jones & Bartlett Publishers
Published: 2004
International: No

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How the Human Genome Works - 04 edition

ISBN13: 978-0763723842

Edwin H. McConkey

ISBN13: 978-0763723842
ISBN10: 0763723843
Cover type: Print On Demand
Edition/Copyright: 04
Publisher: Jones & Bartlett Publishers

Published: 2004
International: No
Summary

This unique text explains the basics of the human genome: what it is, what it does, and its implications in health and disease. In seven clear and concise "Lectures," Dr. McConkey conveys the essentials of what we know about genes and gene expression, how mutations lead to simple and complex disorders, and how the rapid advance in our understanding of the human genome is impacting the practice of medicine. How the Human Genome Works will be useful for people in the health sciences at all levels, from students to established professionals, who want to update their knowledge about human genetics without making a major time commitment. This brief book, which can be read in a few sittings, will provide you with a broad basic understanding of this complex topic. It is the ideal text for science, medical, and nursing students, practicing physicians and nurses, and all others who need a readable overview of human genetics.

Table of Contents

Lecture 1. Natural History of the Human Genome

General Aspects of the Genome
What's in a Gene?
Repetitive DNA
Chromatin
Gene Expression

Lecture 2. The Mechanisms of Mutation: How the Human Genome Changes

Spontaneous Mutations
Induced Mutations
The Human Mutation Rate

Lecture 3. Genetic Diseases: The Consequences of Mutation

Mendelian Inheritance of Autosomal Genes
Mendelian Inheritance of X and Y Chromosome Genes
From Mendel to Genes
On Beyond Mendel: Complex Inheritance
Genomic Imprinting

Lecture 4. The Human Genome and Medical Practice

Genetic Screening
Therapy of Genetic Disorders

Lecture 5. The Mitochondrial Genome and Mitochondrial Disorders

Mitochondrial Genetic Diseases

Lecture 6. The Genetic Basis of Cancer

Oncogenes
Tumor-Suppressor Genes
Loss of Growth Control

Lecture 7. The Human Genome and Developmental Biology

Prenatal Developmental Genetics
Genetics of Aging
A Look Ahead
Glossary
Index

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