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Immune System

Immune System - 3rd edition

ISBN13: 978-0815341468

Cover of Immune System 3RD 09 (ISBN 978-0815341468)
ISBN13: 978-0815341468
ISBN10: 0815341466
Cover type: Paperback
Edition/Copyright: 3RD 09
Publisher: Garland Publishing
Published: 2009
International: No

List price: $127.00

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Immune System - 3RD 09 edition

ISBN13: 978-0815341468

Peter Parham

ISBN13: 978-0815341468
ISBN10: 0815341466
Cover type: Paperback
Edition/Copyright: 3RD 09
Publisher: Garland Publishing

Published: 2009
International: No

The Immune System, Third Edition emphasizes the human immune system and synthesizes immunological concepts into a comprehensible, up-to-date, and reader-friendly account of how the immune system works.

Written for undergraduate, medical, veterinary, dental, and pharmacy students in immunology courses, it makes generous use of medical examples to illustrate points.

The Third Edition has been extensively revised and updated and includes two new chapters on innate and adaptive immunity, which explore the physical, cellular, and molecular principles underlying these responses to infection. It also features enhanced coverage of aspects of innate immunity such as the complement system, Toll-like receptors, defensins, and C-reactive protein; the role of dendritic cells in initiating the primary adaptive immune response and the functions of other cells that bridge innate and adaptive immunity; immunotherapies using humanized monoclonal antibodies to treat certain diseases; and the nature of the immune response in the mucosal tissues and immunological memory. The book offers over 500 full-color illustrations that complement and clarify the concepts. The end-of-chapter questions have been expanded and include essay, multiple-choice, and case study questions, with answers provided at the end of the book.

Author Bio

Peter Parham is on the faculty at Stanford University where he is a Professor in the Departments of Structural Biology, and Microbiology and Immunology.

Table of Contents

Table of Contents
Chapter 1: Elements of the Immune System and their Roles in Defense. Defenses facing invading pathogens. Principles of adaptive immunity.

Chapter 2: Antibody Structure and the Generation of B-Cell Diversity. The structural basis of antibody diversity. Generation of immunoglobulin diversity in B cells before encounter with antigen. Diversification of antibodies after B cells encounter antigen.

Chapter 3: Antigen Recognition by T Lymphocytes. T-cell receptor diversity. Antigen processing and presentation. The major histocompatibility complex.

Chapter 4: The Development of B Lymphocytes. The development of B cells in the bone marrow. Selection and further development of the B-cell repertoire.

Chapter 5: The Development of T Lymphocytes. The development of T cells in the thymus. Positive and negative selection of the T-cell repertoire.

Chapter 6: T-Cell Mediated Immunity. Activation of naive T cells on encounter with antigen. The properties and functions of effector T cells.

Chapter 7: Immunity Mediated by B Cells and Antibodies. Antibody production by B lymphocytes. Antibody effector functions. The antigen-antibody mediated pathway of complement activation.

Chapter 8: The Body's Defenses Against Infection. Innate immunity. Adaptive immune responses to infection. Immunological memory and the secondary immune response.

Chapter 9: Failures of the Body's Defenses. Evasion and subversion of the immune system by pathogens. Inherited immunodeficiency diseases. Acquired Immune Deficiency Syndrome.

Chapter 10: Over-reactions of the Immune System. Type I hypersensitivity reactions. Types II, III, and IV hypersensitivity reactions.

Chapter 11: Disruption of Healthy Tissue by the Immune Response. Autoimmune diseases. Genetic and environmental factors which predispose to autoimmune disease.

Chapter 12: Manipulation of the Immune Response. Prevention of infectious disease by vaccination. Transplantation of tissues and organs. Cancer and its interactions with the immune system.

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