Summary: Covers principles of inheritence, genetic mapping, molecular genetics, development; population genetics.
Edition/Copyright:7TH 00 Cover: Hardback Publisher:W.H. Freeman Published: 02/28/2000 International: No
View Author Bio
Griffiths, Anthony J.F. : University of British Columbia
Miller, Jeffrey H. : University of California, Los Angeles
Suzuki, David : University of British Columbia
Lewontin, Richard C. : Harvard University
Gelbart, William M. : Harvard University
View Table of Contents
1 Genetics and the Organism Genes as Determinants of the Inherent Properties of Species Genetic Variation Methodologies Used in Genetics Genes, the Environment, and the Organism 2 Patterns of Inheritance Mendel's Experiments Using Genetic Ratios Sex Chromosomes and Sex-Linked Inheritance Human Genetics 3 Chromosomal Basis of Heredity Historical Development of the Chromosome Theory Mendelian Genetics in Eukaryotic Life Cycles Topography of the Chromosome Set Three-Dimensional Structure of Chromosomes 4 Gene Interaction From Genes to Phenotypes A Diagnostic Test for Alleles Interactions Between the Alleles of One Gene Gene Interaction and Modified Dihybrid Ratios Gene Interaction in Petal Color of Foxgloves Gene Interaction in Coat Color of Mammals Penetrance and Expressivity Chi-Square Test Genetic Mapping 5 Basic Eukaryotic Chromosome Mapping The Discovery of Linkage Recombination Linkage Symbolism Linkage of Genes on the X Chromosome Linkage Maps Three-Point Testcross Interference Calculating Recombinant Frequencies from Selfed Dihybrids Examples of Linkage Maps Chi-Square Test for Linkage Mapping with Molecular Markers Linkage Mapping by Recombination in Humans Nature of Crossing-Over 6 Specialized Eukaryotic Chromosome Mapping Techniques Accurate Calculation of Large Map Distances Analysis of Single Meioses Mapping Genes by Mitotic Segregation and Recombination Mapping by In Situ Hybridization Mapping Human Genes by Using Human-Rodent Somatic Cell Hybrids 7 Gene Transfer in Bacteria and Their Viruses Working with Microorganisms Bacterial Conjugation Bacterial Transformation Bacteriophage Genetics Transduction Chromosome Mapping Bacterial Gene Transfer in Review Molecular Genetics 8 The Structure and Replication of DNA DNA: The Genetic Material Structure of DNA Replication of DNA Mechanism of DNA Replication 9 Genetics of DNA Function How Genes Work Gene-Protein Relations Genetic Fine Structure Mutational Sites Complementation 10 Molecular Biology of Gene Function Properties of RNA Transcription Transcription and RNA Polymerase Eukaryotic RNA Translation Genetic Code Protein Synthesis Universality of Genetic Information Transfer Functional Division of Labor in the Gene Set 11 Regulation of Gene Transcription Basic Control Circuits Discovery of the lac System: Negative Control Catabolite Repression of the lac Operon: Positive Control Positive and Negative Control Dual Positive and Negative Control: The Arabinose Operon Metabolic Pathways Additional Examples of Control: Attenuation Lambda Phage: A Complex of Operons Transcription: An Overview of Gene Regulation in Eukaryotes Regulation of Transcription Factors Epigenetic Inheritance 12 Recombinant DNA Technology Making Recombinant DNA Cloning a Specific Gene Using Cloned DNA 13 Applications of Recombinant DNA Technology In Vitro Mutagenesis RFLP Mapping Reverse Genetics Expressing Eukaryotic Genes in Bacteria Recombinant DNA Technology in Eukaryotes Gene Therapy Using Recombinant DNA to Detect Disease Alleles Directly 14 Genomics Genomics: An Overview Genome Projects: Practical Considerations Structural Genomics Functional Genomics Generation of Genetic Variation 15 Gene Mutation How DNA Changes Affect Phenotype Somatic Versus Germinal Mutation Mutant Types Occurrence of Mutations Selective Systems Mutation Induction Mutation and Cancer Mutagens in Genetic Dissection Mutation Breeding 16 Mechanisms of Gene Mutation Molecular Basis of Gene Mutations Spontaneous Mutations Induced Mutations Reversion Analysis Relation Between Mutagens and Carcinogens Biological Repair Mechanisms Repair Defects and Human Diseases 17 Chromosome Mutation I: Changes in Chromosome Structure Origin of Changes in Chromosome Structure Deletions Duplications Inversions Translocations Diagnosis of Rearrangments by Tetrad Analysis 18 Chromosome Mutation II: Changes in Chromosome Number Aberrant Euploidy Aneuploidy Mechanisms of Gene Imbalance Chromosome Mechanics in Plant Breeding 19 Mechanisms of Recombination Breakage and Reunion of DNA Molecules Chiasmata: The Crossover Points Genetic Results Leading to Recombination Models Holliday Model Enzymatic Mechanism of Recombination 20 Transposable Genetic Elements Controlling Elements in Maize Bacterial Insertion Sequences Prokaryotic Transposons Mechanism of Transposition in Prokaryotes Review of Transposable Elements in Prokaryotes Molecular Nature of Transposable Elements in Eukaryotes Review of Transposable Elements in Eukaryotes Development 21 Extranuclear Genes Origin of Extranuclear Genes Structure of Organelle Chromosomes Organelle Mutations Inheritance of Organelle Genes and Mutations Recombination of Extranuclear DNA Cytoplasmic Male Sterility Mitochondria and Aging 22 Cancer as a Genetic Disease Cancer and the Control of Cell Number: An Overview Cell Proliferation Machinery Machinery for Programmed Cell Death Controlling the Cell-Proliferation and Death Machinery Cancer: The Genetics of Aberrant Cell Control Cancer Research in the Genomic Analysis Era 23 Developmental Genetics Central Themes of Developmental Genetics Gene Regulation at Levels Other Than Transcription Initiation: Examples Binary Fate Decisions: Pathways of Sex Determination Drosophila Sex Determination: Every Cell for Itself Sex Determination in Mammals: Coordinated Control by the Endocrine System Binary Fate Decisions: The Germ Line versus the Soma Forming Complex Pattern: Establishing Positional Information Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates Additional Aspects of Pattern Formation The Many Parallels in Vertebrate and Insect Pattern Formation Do the Lessons of Animal Development Apply to Plants? Genes at the Population Level 24 Population Genetics Variation and Its Modulation Effect of Sexual Reproduction on Variation Sources of Variation Selection Balanced Polymorphism Artificial Selection Random Events 25 Quantitative Genetics Some Basic Statistical Notions Genotypes and Phenotypic Distribution Norm of Reaction and Phenotypic Distribution Determining Norms of Reaction Heritability of a Trait Quantifying Heritability Locating the Genes More on Analyzing Variance 26 Evolutionary Genetics A Synthesis of Forces: Variation and Divergence of Populations Multiple Adaptive Peaks Heritability of Variation Observed Variation Within and Between Populations Process of Speciation Origin of New Genes Rate of Molecular Evolution Appendix Genetic Nomenclature Further Readings Glossary Answers to Selected Problems Index
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