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Introduction to Genetic Analysis / With CD and Solution Manual

Introduction to Genetic Analysis / With CD and Solution Manual - 7th edition

ISBN13: 978-0716741831

Cover of Introduction to Genetic Analysis / With CD and Solution Manual 7TH 00 (ISBN 978-0716741831)
ISBN13: 978-0716741831
ISBN10: 0716741830
Cover type:
Edition/Copyright: 7TH 00
Publisher: W.H. Freeman
Published: 2000
International: No

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Introduction to Genetic Analysis / With CD and Solution Manual - 7TH 00 edition

ISBN13: 978-0716741831

Anthony Griffiths, Jeffrey Miller, David Suzuki, Lewontin and Gelbart

ISBN13: 978-0716741831
ISBN10: 0716741830
Cover type:
Edition/Copyright: 7TH 00
Publisher: W.H. Freeman

Published: 2000
International: No

Covers principles of inheritence, genetic mapping, molecular genetics, development; population genetics.

Author Bio

Griffiths, Anthony J.F. : University of British Columbia

Miller, Jeffrey H. : University of California, Los Angeles

Suzuki, David : University of British Columbia

Lewontin, Richard C. : Harvard University

Gelbart, William M. : Harvard University

Table of Contents

1 Genetics and the Organism

Genes as Determinants of the Inherent Properties of Species
Genetic Variation
Methodologies Used in Genetics
Genes, the Environment, and the Organism

2 Patterns of Inheritance

Mendel's Experiments
Using Genetic Ratios
Sex Chromosomes and Sex-Linked Inheritance
Human Genetics

3 Chromosomal Basis of Heredity

Historical Development of the Chromosome Theory
Mendelian Genetics in Eukaryotic Life Cycles
Topography of the Chromosome Set
Three-Dimensional Structure of Chromosomes
Sequence Organization

4 Gene Interaction

From Genes to Phenotypes
A Diagnostic Test for Alleles
Interactions Between the Alleles of One Gene
Gene Interaction and Modified Dihybrid Ratios
Gene Interaction in Petal Color of Foxgloves
Gene Interaction in Coat Color of Mammals
Penetrance and Expressivity
Chi-Square Test
Genetic Mapping

5 Basic Eukaryotic Chromosome Mapping

The Discovery of Linkage
Linkage Symbolism
Linkage of Genes on the X Chromosome
Linkage Maps
Three-Point Testcross
Calculating Recombinant Frequencies from Selfed Dihybrids
Examples of Linkage Maps
Chi-Square Test for Linkage
Mapping with Molecular Markers
Linkage Mapping by Recombination in Humans
Nature of Crossing-Over

6 Specialized Eukaryotic Chromosome Mapping Techniques

Accurate Calculation of Large Map Distances
Analysis of Single Meioses
Mapping Genes by Mitotic Segregation and Recombination
Mapping by In Situ Hybridization
Mapping Human Genes by Using Human-Rodent Somatic Cell Hybrids

7 Gene Transfer in Bacteria and Their Viruses

Working with Microorganisms
Bacterial Conjugation
Bacterial Transformation
Bacteriophage Genetics
Chromosome Mapping
Bacterial Gene Transfer in Review
Molecular Genetics

8 The Structure and Replication of DNA

DNA: The Genetic Material
Structure of DNA
Replication of DNA
Mechanism of DNA Replication

9 Genetics of DNA Function

How Genes Work
Gene-Protein Relations
Genetic Fine Structure
Mutational Sites

10 Molecular Biology of Gene Function

Properties of RNA
Transcription and RNA Polymerase
Eukaryotic RNA
Genetic Code
Protein Synthesis
Universality of Genetic Information Transfer
Functional Division of Labor in the Gene Set

11 Regulation of Gene Transcription

Basic Control Circuits
Discovery of the lac System: Negative Control
Catabolite Repression of the lac Operon: Positive Control
Positive and Negative Control
Dual Positive and Negative Control: The Arabinose Operon
Metabolic Pathways
Additional Examples of Control: Attenuation
Lambda Phage: A Complex of Operons
Transcription: An Overview of Gene Regulation in Eukaryotes
Regulation of Transcription Factors
Epigenetic Inheritance

12 Recombinant DNA Technology

Making Recombinant DNA
Cloning a Specific Gene
Using Cloned DNA

13 Applications of Recombinant DNA Technology

In Vitro Mutagenesis
RFLP Mapping
Reverse Genetics
Expressing Eukaryotic Genes in Bacteria
Recombinant DNA Technology in Eukaryotes
Gene Therapy
Using Recombinant DNA to Detect Disease Alleles Directly

14 Genomics

Genomics: An Overview
Genome Projects: Practical Considerations
Structural Genomics
Functional Genomics
Generation of Genetic Variation

15 Gene Mutation

How DNA Changes Affect Phenotype
Somatic Versus Germinal Mutation
Mutant Types
Occurrence of Mutations
Selective Systems
Mutation Induction
Mutation and Cancer
Mutagens in Genetic Dissection
Mutation Breeding

16 Mechanisms of Gene Mutation

Molecular Basis of Gene Mutations
Spontaneous Mutations
Induced Mutations
Reversion Analysis
Relation Between Mutagens and Carcinogens
Biological Repair Mechanisms
Repair Defects and Human Diseases

17 Chromosome Mutation I: Changes in Chromosome Structure

Origin of Changes in Chromosome Structure
Diagnosis of Rearrangments by Tetrad Analysis

18 Chromosome Mutation II: Changes in Chromosome Number

Aberrant Euploidy
Mechanisms of Gene Imbalance
Chromosome Mechanics in Plant Breeding

19 Mechanisms of Recombination

Breakage and Reunion of DNA Molecules
Chiasmata: The Crossover Points
Genetic Results Leading to Recombination Models
Holliday Model
Enzymatic Mechanism of Recombination

20 Transposable Genetic Elements

Controlling Elements in Maize
Bacterial Insertion Sequences
Prokaryotic Transposons
Mechanism of Transposition in Prokaryotes
Review of Transposable Elements in Prokaryotes
Molecular Nature of Transposable Elements in Eukaryotes
Review of Transposable Elements in Eukaryotes

21 Extranuclear Genes

Origin of Extranuclear Genes
Structure of Organelle Chromosomes
Organelle Mutations
Inheritance of Organelle Genes and Mutations
Recombination of Extranuclear DNA
Cytoplasmic Male Sterility
Mitochondria and Aging

22 Cancer as a Genetic Disease

Cancer and the Control of Cell Number: An Overview
Cell Proliferation Machinery
Machinery for Programmed Cell Death
Controlling the Cell-Proliferation and Death Machinery
Cancer: The Genetics of Aberrant Cell Control
Cancer Research in the Genomic Analysis Era

23 Developmental Genetics

Central Themes of Developmental Genetics
Gene Regulation at Levels Other Than Transcription Initiation: Examples
Binary Fate Decisions: Pathways of Sex Determination
Drosophila Sex Determination: Every Cell for Itself
Sex Determination in Mammals: Coordinated Control by the Endocrine System
Binary Fate Decisions: The Germ Line versus the Soma
Forming Complex Pattern: Establishing Positional Information
Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates
Additional Aspects of Pattern Formation
The Many Parallels in Vertebrate and Insect Pattern Formation
Do the Lessons of Animal Development Apply to Plants?
Genes at the Population Level

24 Population Genetics

Variation and Its Modulation
Effect of Sexual Reproduction on Variation
Sources of Variation
Balanced Polymorphism
Artificial Selection
Random Events

25 Quantitative Genetics

Some Basic Statistical Notions
Genotypes and Phenotypic Distribution
Norm of Reaction and Phenotypic Distribution
Determining Norms of Reaction
Heritability of a Trait
Quantifying Heritability
Locating the Genes
More on Analyzing Variance

26 Evolutionary Genetics

A Synthesis of Forces: Variation and Divergence of Populations
Multiple Adaptive Peaks
Heritability of Variation
Observed Variation Within and Between Populations
Process of Speciation
Origin of New Genes
Rate of Molecular Evolution
Appendix Genetic Nomenclature
Further Readings
Answers to Selected Problems


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