Lehninger Principles Of Biochemistry - 5th edition

Summary: This undergraduate textbook describes the structure and function of the major classes of cellular constituents, and explains the physical, chemical, and biological context in which each biomolecule, reaction, and pathway operates.

MAJOR RECENT ADVANCES IN BIOCHEMISTRY
Thoroughly revised throughout, the new edition incorporates new research on the
expanded role of RNA in biology, hormonal regulation of metabolism and its relation to obesity and dia ...show morebetes, new methods in bioinformatics, and the application of biochemistry to medicine, forensics, and agriculture. New discussions include:
--Introduction to proteomes and proteomics (Chapter 1)
--Amyloid diseases in the context of protein folding (Chapter 4)
--Pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples (Chapter 6)
--Sugar analogs as drugs that target viral neuraminidase (Chapter 7)
--Green fluorescent protein (Chapter 9)
--Lipidomics (Chapter 10)
--Volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods (Chapter 10)
--Lipid rafts and caveolae (Chapter 11)
--The emerging role of ribulose 5-phosphate as central regulator of glycolysis and gluconeogenesis (Chapter 15)
--Moonlighting Enzymes: Proteins with More Than One Job (Box 16-1)
--The role of transcription factors (PPARs) in regulation of lipid catabolism (Chapter 17)
--Fatty acid synthase, including new structural information on FAS I (Chapter 21)
--Epigenetics, Nucleosome Structure, and Histone Variants, on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity (Box 24-2)
--Initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism (Chapter 25)
--The roles of RNA in cells (Chapter 26)
--The roles of RNA in protein biosynthesis (Chapter 27)
--Riboswitches (Chapter 28)
--Of Fins, Wings, Beaks, and Things, on the connections between evolution and development (Box 28-1) ...show less

Edition/Copyright: 5TH 08
Cover: Hardback
Publisher: W.H. Freeman
Published: 02/01/2008

View Table of Contents

Table of Contents

1. The Foundations of Biochemistry

PART I. STRUCTURE AND CATALYSIS
2. Water
3. Amino Acids, Peptides, and Proteins
4. The Three-Dimensional Structure of Proteins
5. Protein Function
6. Enzymes
7. Carbohydrates and Glycobiology
8. Nucleotides and Nucleic Acids
9. DNA-Based Information Technologies
10. Lipids
11. Biological Membranes and Transport
12. Biosignaling

PART II: BIOENERGETICS AND METABOLISM
13. Principles of Bioenergetics
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
15. Principles of Metabolic Regulation: Glucose and Glycogen Metabolism
16. The Citric Acid Cycle
17. Fatty Acid Catabolism
18. Amino Acid Oxidation and the Production of Urea
19. Oxidative Phosphorylation and Photophosphorylation
20. Carbohydrate Biosynthesis in Plants and Bacteria
21. Lipid Biosynthesis
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
23. Hormonal Regulation and Integration of Mammalian Metabolism

PART III. INFORMATION PATHWAYS
24. Genes and Chromosomes
25. DNA Metabolism
26. RNA Metabolism
27. Protein Metabolism
28. Regulation of Gene Expression

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