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Life : The Science of Biology, Volume I - Text Only

Life : The Science of Biology, Volume I - Text Only - 6th edition

ISBN13: 978-0716743484

Cover of Life : The Science of Biology, Volume I - Text Only 6TH 01 (ISBN 978-0716743484)
ISBN13: 978-0716743484
ISBN10: 0716743485
Cover type:
Edition/Copyright: 6TH 01
Publisher: Sinauer Associates, Inc.
Published: 2001
International: No

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Life : The Science of Biology, Volume I - Text Only - 6TH 01 edition

ISBN13: 978-0716743484

William K. Purves, David Sadava, Gordon H. Orians and Craig Heller

ISBN13: 978-0716743484
ISBN10: 0716743485
Cover type:
Edition/Copyright: 6TH 01
Publisher: Sinauer Associates, Inc.

Published: 2001
International: No

Establishing biology as a dynamic discipline--not just a collection of facts--Life develops students' conceptual understanding of biological processes with impeccable scholarship, a smooth narrative, experimental contexts, spectacular art and effective pedagogy. In the streamlined new edition, you will find a strongly enhanced art program--with new features that zero in on the stages of key experiments and methodology, and that further clarify complex processes. Also for this edition: a new chapter on cell signaling, expanded coverage of plant and animal diversity, and an expansive, well-focused media/supplements package offering a new component for students (Lecture Notebook) and new options for Instructors such as online quizzing and testing, new presentation tools, custom lab manuals, WebCT, and more.

Author Bio

Purves, William K. : Harvey Mudd College

Sadava, David : Claremont Graduate University / Claremont McKenna College

Orians, Gordon H. : University of Washington

Heller, Craig : Stanford University

Table of Contents

1. An Evolutionary Framework for Biology

2. Small Molecules: Structure and Behavior

More focus on biologically related chemistry, including acid and bases and electronegativity. Less emphasis on pure chemistry. Isotopes in medicine.

3. Macromolecules: Their Chemistry and Biology

Reorganized to put polymers (carbohydrates, proteins, nucleic acids) first. Focused, biologically related discussion of the role of protein surfaces in chemical interactions. This relationship of structure and function is reiterated later in Part I (e.g., membrane transport, enzymes).

4. The Organization of Cells

The older methods section on cell fractionation/organelle isolation has been eliminated. The chapter has been reorganized to put the endomembane system earlier. Emphasis on the roles of organelles, as well as their structures.

5. Cellular Membranes

Major new discussion of homotypic and heterotypic cell binding as an important membrane function. This sets the stage for later descriptions of development. The membrane transport sections have been reorganized for more clarity of the differences between facilitated and active transport. Much of the material on cell communication has been moved to the new chapter (15).

6. Energy, Enzymes, and Metabolism

The emphasis on protein structure/binding reiterates Chapter 3. The discussions of thermodynamics have been refocused for biological emphasis. New section on what happens during catalysis.

7. Cellular Pathways That Harvest Chemical Energy

The discussion of the chemiosmotic mechanism are clearer, with emphasis on membranes and equilibrium. Two important experiments that helped prove chemiosmosis are described. There is a new section on metabolic interrelationships among pathways e.g., transaminations. The role of the citric acid cycle as the center of metabolism is emphasized.

8. Photosynthesis: Energy from the Sun

New section on plant metabolic relationships: Calvin, citric cycles, and glycolysis. This puts the carbon fixed in photosynthesis in an overall perspective. There is new emphasis on the ecological adaptations of C3 and C4 photosynthesis and less on the precise biochemistry. These pathways are placed in evolutionary perspective.

9. Chromosomes, the Cell Cycle, and Cell Division

New and updated discussions on the checkpoints of the cell cycle, the bacterial cell cycle and the centrosome cycle.

10. Transmission Genetics: Mendel and Beyond

Human pedigree analysis has been woven into the descriptions of Mendelian and sex-linked genetics. There is a new discussion of cytoplasmic inheritance in mitochondria and diseases that arise from it. There is also a description of hybrid vigor in agricultural genetics.

11. DNA and Its Role in Heredity

The discussion of DNA replication has been updated to describe the stationary replication machine, with DNA threading through. PCR and DNA sequencing are now in this chapter, as they are applications of DNA replication and they are used in chapters 12-14.

12. From DNA to Protein: Genotype to Phenotype

New section of post-translational events such as protein targeting and protein modifications such as glycosylation, phosphorylation, and proteolysis. The contemporary 4 site model of tRNA on ribosome is described but there is still an emphasis on the A&P sites.

13. The Genetics of Viruses and Prokaryotes

The material on bacterial genetics and phage mapping has been trimmed down and replaced with a new section on prokaryotic genomes: sequences, the minimal cell and functional genomics. There is a new section on phage lambda operon control of lysis vs lysogeny and also one on the strategy of virus replication.

14. The Eukaryotic Genome and Its Expression

New section on genomes: yeast building on bacteria and worm building on yeast and fruit fly building on worm, etc. There is less emphasis on repetitive sequences and a new section on chromatin remodeling and transcription. The role of the proteasome in protein degradation is also a current topic.

15. Cell Signaling and Communication

This is a new chapter on cell signaling. It comes at this place in the book because this is where the students have the background for it. The chapter uses and reinforces concepts of membranes (chapter 5), protein structrure and binding (chapter 3), cell division (chapter 9), enzyme activation (chapter 6), protein synthesis (chapter 12), gene regulation (chapter 14). It is also a prelude to the important roles of cell signaling in development (chapter 16), diseases (chapter 18) and the immune system (chapter 19). The major concept that focuses most of the chapter is the signal transduction pathway. This is clearly described in the context of signaling in many organisms, ranging from bacteria to humans. Among the newer aspects described is the role of nitric oxide as a second messenger. The chapter ends with a presentation of how signals get from cell to cell by gap junctions in animals and plasmodesmata in plants.

16. Development: Differential Gene Expression

Increased emphasis on contemporary experiments on cloning (sheep, mice, cows), as well as the use of stem cells in medicine and biology. There is additional material on plant organ identity genes. A new sections on ''evodevo'': evolution and development, introduces this new field.

17. Recombinant DNA and Biotechnology

This chapter has a more applied focus and is less techniques oriented. For example, there is a new section on pharming (making new proteins in milk) as well as making knockouts, a valuable research tool. There is also a new section on DNA chips.

18. Molecular Biology and Medicine

Prions are described in this chapter rather than one on prokaryotes and viruses, since prions are not viruses. The results of the first preliminary human genome sequences are presented and debated. There is an updated sction on cancer, with tumor suppressor genes: roles and locations to parallel oncogenes.

19. Natural Defenses against Disease

Clear focus on cellular immunity and a new sections on AIDS treatment and immune regulation.

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