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Summary: From the authors of the bestselling Introduction to Genetic Analysis comes a pioneering genetics text--Modern Genetics Analysis. Its complete integration of classical and molecular genetics makes Modern Genetics Analysis the alternative introductory genetics text instructors have been asking for.
Griffiths, Anthony J. F. : University of British Columbia
Gelbart, William M. : Harvard University
Miller, Jeffery H. : University of California-Los Angeles
Lewontin, Richard C. : Harvard University
Chapter 1 GENETICS AND THE ORGANISM
The book begins by describing the relationship between phenotype and genotype and stressing the types and importance of genetic variation.
Genetics and Human Affairs
Genetics and Biology
Genetics Begins with Variation
Chapter 2 THE STRUCTURE OF GENES AND GENOMES
Chapter 2 presents the molecular nature of the hereditary material and establishes the hierarchy of DNA, chromosomes, chromatin, and genomes.
The Nature of DNA
The Nature of Genes
The Nature of Genomes
The Nature of Eukaryotic Nuclear Chromosomes
Chapter 3 GENE FUNCTION
The flow of information from DNA to RNA to protein, introduced in Chapters 1 and 2, is described fully. The molecular nature of the gene/phenotype relationship is demonstrated through mutational analysis.
Genes and RNA
Making Functional Transcripts
Protein Function and Malfunction in Cells
Defective Proteins and Dominance and Recessiveness
Functional Division of Labor in the Gene Set
Chapter 4 THE INHERITANCE OF GENES
In this chapter, DNA replication is established as the basis of inheritance. Mitosis and meiosis are related to the molecular nature of the genetic material. The inheritance patterns of single genes, both autosomal and sex-linked, is presented. Human pedigree analyses, which integrate both classical and molecular approaches, include: autosomal recessive disorders (PKU and albinism); autosomal dominant disorders (achondroplasia and Huntington's disease); and X-linked disorder.
Inheritance Patterns of Individual Genes
Human Pedigree Analysis
Inheritance of Organelle Genes
Chapter 5 RECOMBINATION OF GENES
Expanding on the previous chapter, Chapter 5 analyzes coincident inheritance patterns where two or more genes are involved. It juxtaposes the two types of recombination--independent assortment and crossing over--and demonstrates how recombinant frequencies are used to create linkage maps.
The Mechanism of Crossing-over
Recombination within a Gene
Chapter 6 GENE INTERACTION
Inheritance patterns, covered in Chapters 4 and 5, are now related to gene interactions at the molecular level. First, the complementation test for allelism is presented. Then, both allelic (e.g., incomplete dominance in four o'clock plants and codominance in the human ABO blood groups), and non-allelic interactions (e.g., petal color in plants) are examined at the molecular and cellular levels.
From Genes to Phenotypes
A Diagnostic Test for Alleles
Interactions between the Alleles of One Gene
Penetrance and Expressivity
Chapter 7 GENE MUTATIONS
Students study the molecular nature and mechanisms of mutation, reinforcing the hierarchical relationship between genes, protein products, and phenotype. Students are also introduceded to the use of mutants in the genetic dissection of biological function.
The Molecular Basis of Mutation
Chapter 8 CHROMOSOME MUTATIONS
The origin and inheritance of changes in chromosome structure and number are discussed and integrated via the concepts of gene imbalance and evolutionary divergence.
Changes in Chromosome Number
The Overall Incidence of Human Chromosome Mutations
Evolution of the Genome
Chapter 9 THE GENTETICS OF BACTERIA AND PHAGES
The mechanisms and consequences of bacterial gene transfer, and bacteriophage genetics, are presented and applied to mapping bacterial and phage chromosomes. This material also sets the stage for subsequent chapters on recombinant DNA technology.
Working with Microorganisms
Bacterial Gene Transfer in Review
Chapter 10 RECOMBINANT DNA TECHNOLOGY
The chapter presents the technology used to isolate and clone a gene. These
techniques are then applied to the isolation and characterization of specific genes
including the alkaptonuria gene.
Making Recombinant DNA
Cloning a Specific Gene
Using Cloned DNA
Chapter 11 APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY
This chapter builds on Chapter 10 by surveying the opportunities available once a gene has been isolated. Examples discussed include, transgenic plants that are resistant to weedkillers, transgenic mice corrected for growth hormone deficiency, and somatic cell gene therapy in humans.
In Vitro Mutagenesis
Expressing Eukaryotic Genes in Bacteria
Recombinant DNA Technology in Eukaryotes
Using Recombinant DNA to Detect Disease Alleles Directly
Chapter 12 GENOMICS
The third chapter in the book's recombinant DNA technology "trilogy" presents the techniques and applications of handling and characterizing whole genomes, including positional cloning of human disease genes and the use of DNA chips in functional genomics.
Chapter 13 MECHANISMS OF GENETIC CHANGE: TRANSPOSABLE GENETIC ELEMENTS
Discusses the nature of mobile genetic elements and their effects on genetic change and genome evolution.
Mechanism of Transposition
Rearrangements Mediated by Transposable Elements
Review of Transposable Elements in Prokaryotes
Ty Elements in Yeast
Transposable Elements in Drosophila
Transposition through an RNA Intermediate
Controlling Elements in Maize
Review of Transposable Elements in Eukaryotes
Chapter 14 REGULATION OF GENE TRANSCRIPTION
Discussions of both eukaryotic and prokaryotic regulation of gene expression emphasize common themes, such as the sequence specific binding of allosterically regulated proteins to DNA, and the response of regulatory elements to environmental signals. Epigenetic phenomenea, such as parental imprinting, are also discussed.
The Logic of Prokaryotic Gene Regulation
The Basics of Prokaryotic Transcriptional Regulation
Regulation of the Lactose System
Dual Positive and Negative Control: The Arabinose Operon
Transcription: Gene Regulation in Eukaryotes--An Overview
Regulation of Transcription Factors
Chapter 15 GENETIC MECHANISMS REGULATING CELL NUMBER
The machinery of both cell proliferation and programmed cell death is examined, with particular emphasis on the interconnectedness of these pathways via signals from both external and internal environments. Cancer is then examined as a genetic disease of somatic cells, arising from sequential mutations that perturb normal cell proliferation and cell death processes.
Cancer and the Control of Cell Number: An Overview
The Cell Proliferation Machinery
The Machinery for Programmed Cell Death
Controlling the Cell Proliferation and Death Machinery
Cancer: The Genetics of Aberrant Cell Control
Chapter 16 THE GENETIC BASIS OF DEVELOPMENT
Building on the basic concepts of regulation and intercellular communication developed in the preceding two chapters, Chapter 16 covers simple developmental switches, such as those governing Drosophila and mammalian sex determination. It explores pattern formation as a sequence of ever-finer cell fate decisions. The conservation of developmental mechanisms among all animal systems is exemplified with the patterning genes of insects and mammals.
Central Themes of Developmental Genetics
Binary Fate Decisions: Pathways of Sex Determination
Drosophila Sex Determination: Every Cell for Itself
Sex Determination in Mammals: Coordinated Control by an Endocrine Organ
Binary Fate Decisions: The Germ Line versus the Soma
Forming Complex Pattern: Establishing Positional Information
Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates
Additional Aspects of Pattern Formation
The Many Parallels in Vertebrate and Insect Pattern Formation
Chapter 17 POPULATION GENETICS
This chapter examines variation within a population at morphological, protein, and DNA levels. Change of a population's genetic structure resulting from an interaction of evolutionary forces is emphasized.
Variation and Its Modulation
The Effect of Sexual Reproduction on Variation
The Sources of Variation
Multiple Adaptive Peaks
A Synthesis of Forces
Chapter 18 QUANTITATIVE GENETICS
With this chapter, students understand what quantitative variation is, how it is measured, and how environment and genotype contribute to phenotypic variation. The analysis shows the uses and misuses of estimates of heritability.
Some Basic Statistical Notions
Genotypes and Phenotypic Distribution
Norm of Reaction and Phenotypic Distribution
Determining Norms of Reaction
The Heritability of a Trait
Locating the Genes
More on Analyzing Variance
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