Summary: The new edition of Principles of Biochemistry remains faithful to the vision of its predecessors while embracing the tremendous advances made in biochemical research since the previous edition. As always, the book presents the fundamentals of biochemistry through selected topics, emphasizing the most important recent developments and applications without abandoning the classical core of the subject. The Third Edition is thoroughly contemporary in conten
t, design, and teaching approach, with new material and references throughout, a number of new boxes on applications, striking new graphics, and new problems drawing on real-world examples. Supplements include a superb study guide/solutions manual and an exclusive tutorial Web site based on the Chemscape Chime 3-D molecular viewer.
Summary: The new edition of Principles of Biochemistry remains faithful to the vision of its predecessors while embracing the tremendous advances made in biochemical research since the previous edition. As always, the book presents the fundamentals of biochemistry through selected topics, emphasizing the most important recent developments and applications without abandoning the classical core of the subject. The Third Edition is thoroughly contemporary in content, design, and teaching approach, with new material and references throughout, a number of new boxes on applications, striking new graphics, and new problems drawing on real-world examples. Supplements include a superb study guide/solutions manual and an exclusive tutorial Web site based on the Chemscape Chime 3-D molecular viewer. ...show less
Edition/Copyright:3RD 00 Cover: Hardback Publisher:Worth Publishers, Inc. Published: 03/28/2000 International: No
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I. Foundations of Biochemistry
The basics of life science are presented in clear, informative vignettes. These chapters will be review for most students and an essential foundation for all. Revised art, additional material on chemical basics, and other revisions based on input from users of the best-selling Second Edition make these chapters more effective for today's students. 1. The Molecular Logic of Life Up-to-date information on available genomic sequences; improved descriptions and illlustrations of energetic relationships in coupled reactions. 2. Cells Rewritten section on the evolution of prokaryotic cells takes into account new information on archaea. 3. Biomolecules New section on chemical reactivity, with ten new figures. 4. Water New sections on colligative properties of aqueous solutions, osmosis and osmotic pressure, and hypotonic lysis of cells
II. Structure and Catalysis
Important revisions and additions bring the central topics of biochemical structure and function completely up to date. 5. Amino Acids and Proteins Now combines material from two chapters in the Second Edition (Ch. 5, Amino Acids and Peptides, and Ch. 6, An Introduction to Proteins) to give students a more coherent introduction to the fundamentals of protein primary structure. Adds new material on current methods, including mass spectrometry and sequence studies. 6. The Three-Dimensional Structure of Proteins This extensively rewritten chapter takes a fresh look at how and why proteins assume their active conformations. It now includes a thorough definition of structural nomenclature, an introduction to information required to explore modern structural databases, an updated discussion of protein folding, and spectacular new molecular graphics. A straightforward and accessible introduction to x-ray crystallography and NMR spectroscopy will add to student appreciation of the hundreds of leading-edge molecular graphics throughout the book. 7. Protein Function This new chapter is an original treatment of structure and function in three instructive cases: the classic allosteric protein hemoglobin, the immunoglobulins, and molecular motors. The chapter includes a rigorous introduction to the physical principles underlying the reversible binding of a ligand to a protein, a topic central to many areas of biochemistry but often underserved in textbooks. 8. Enzymes The treatments of enzyme inhibition and regulation have been updated, including a thorough introduction to the increasingly central topic of phosphorylation in enzyme control. 9. Carbohydrates and Glycoconjugates New material includes coverage of recent topics in glycobiology: the role of carbohydrates in recognition; lectins; selectins; Helicobacter pylori. 10. Nucleotides and Nucleic Acids New material includes coverage of unusual nucleic acid structures and updates material on methods. 11. Lipids Improved pedagogy helps students to learn lipid categories, added material updates the discussion of the metabolic roles of lipids in signaling, and expanded coverage of lipid analysis techniques accents the unique role of lipids in the cell. 12. Biological Membranes and Transport This extensively reorganized chapter brings together the themes of structure and dynamics in biological membranes. Much new information on transport mechanisms has been added, and the foundation is laid for a deeper understanding of signaling (Ch. 13) and membrane-based energetics (Ch. 19). 13. Biosignaling This new chapter reveals the general patterns of signal transduction, followed by detailed summaries of complete signaling pathways using vision, olfaction, and gustation as examples. This chapter also includes a thorough discussion of protein phosphorylation as a regulatory mechanism, exemplified by the control of cell division and apoptosis. The consequences of defective signaling are illustrated in the discussion of oncogenes, tumor suppressor genes, and their defective protein products.
III. Bioenergetics and Metabolism
In the years since the previous edition, much has been added to our knowledge of metabolic regulation and the integration of pathways. Meticulous updating gives students the most recent news-as recent as Spring 1999. 14. Principles of Bioenergetics Improved treatments of displacement reactions, transphosphorylations, the differences between biochemical and chemical equations, and the importance of Mg2+. 15. Glycolysis and the Catabolism of Hexoses Notable improvements include the treatment of channeling, and a new box, "Glucose 6-phosphate dehydrogenase deficiency: Why Pythagoras wouldn't eat falafels." 16. The Citric Acid Cycle New problems and a new discussion of exploring metabolism using NMR. 17. Oxidation of Fatty Acids New problems and a new section on human diseases caused by defects in fatty acid oxidation 18. Amino Acid Oxidation and the Production of Urea Much improved discussion of the integration of amino acid metabolism and other pathways. 19. Oxidative Phosphorylation and Photophosphorylation This extensively revised capstone for the section on catabolism now incorporates the latest structural information about the electron-transport complexes, and the growing consensus about mechanism in biological energy conservation, including the 1998 and 1999 findings on the mechanism of ATP synthase. Major revisions include the role of iron-sulfur proteins, the structures of complexes I, III, IV, and F1 ATP synthase; clearer explanation of the Q cycle; and updated and improved discussions of stoichiometries. 20. Carbohydrate Biosynthesis 21. Lipid Biosynthesis 22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules 23. Integration and Hormonal Regulation of Mammalian Metabolism Extensively revised to complement the revisions throughout the metabolism section.
IV. Information Pathways
While continuing to emphasize fundamentals, these chapters have been brought completely up to date. They record developments in new model organisms, new relations between genes, and the impact of DNA sequencing. New advances are covered thoroughly, including the remarkable advances in the current understanding of eukaryotic transcription and its regulation, and the latest information on cellular protein sorting, DNA metabolism, and genomics. 24. Genes and Chromosomes 25. DNA Metabolism All aspects of DNA metabolism have been extensively revised, including coordination of leading and lagging strands during replication, eukaryotic replication, replication termination, DNA repair mechanisms, and recombination mechanisms. New medical examples have been added. 26. RNA Metabolism Substantial revision includes new information on eukaryotic RNA polymerases and transcription, biochemical evolution, methods, and medical examples. 27. Protein Metabolism Features new material on protein targeting and secretion, and protein degradation. 28. Regulation of Gene Expression Emphasizes the important breakthroughs in the regulation of eukaryotic gene expression, including chromatin remodelling. 29. Recombinant DNA Technology The closing chapter introduces the student to new methods in DNA technology, including genome projects and other major trends.
Appendix A. Common Abbreviations in the Biochemical Research Literature Appendix B. Abbreviated Solutions to Problems Glossary Illustration Credits Index
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