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Structure and Mechnism in Protein Science : A Guide to Enzyme Catalysis and Protein Folding - 99 edition

Structure and Mechnism in Protein Science : A Guide to Enzyme Catalysis and Protein Folding (ISBN10: 0716732688; ISBN13: 9780716732686)
ISBN13: 978-0716732686
ISBN10: 0716732688

Summary: Fourteen years ago when Alan Fersht's Enzyme Structure and Mechanism was published, the field of protein engineering was in its infancy. Since then, spectacular advances in determining biological structure, manipulating genes, engineering proteins, sequencing whole genomes, and computing have led not just to an expansion of protein science, but to its utter transformation. We have entered a new era of protein design, sparked by the convergence of protein foldi ...show moreng and enzymology.

Fersht's Structure and Mechanism in Protein Science is a defining exploration of this new era, an expert depiction of the core principles of protein structure, activity, and mechanism as understood and applied today. A thorough recasting of Fersht's previous text, the book takes a more general look at mechanisms in protein science, emphasizing the unity of concepts in folding and catalysis and the importance of the relationships between basic chemistry, kinetics, thermodynamics, and structure.

By concentrating on fundamental principles and the physical and chemical processes behind them, Structure and Mechanism in Protein Science makes the basic formulas, kinetics, and thermodynamics of protein engineering easier to understand and apply. Up-to-date, authoritative, and full with relevant examples, it provides a solid introduction to a sprawling, still-growing field. For this text, Fersht offers four new chapters showing the impact of protein engineering on protein folding and catalysis (one on enzymology; three on specifics aspects of protein folding). Extensively rewritten chapters cover:

  • three-dimensional structure of proteins
  • practical kinetics
  • conformational change, allosteric regulation, motors, and work
  • forces between molecules
  • recombinant DNA technology
  • case studies of enzyme structure and mechanism
  • allosteric enzymes (expanded with coverage of G and motor proteins)
...show less

Edition/Copyright: 99
Cover: Hardback
Publisher: W.H. Freeman
Year Published: 1999
International: No

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