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Design and Analysis of Clinical Experiments

Design and Analysis of Clinical Experiments - 86 edition

Design and Analysis of Clinical Experiments - 86 edition

ISBN13: 9780471349914

ISBN10: 0471349917

Design and Analysis of Clinical Experiments by Joseph L. Fleiss - ISBN 9780471349914
Edition: 86
Copyright: 1986
Publisher: John Wiley & Sons, Inc.
Published:
International: No
Design and Analysis of Clinical Experiments by Joseph L. Fleiss - ISBN 9780471349914

ISBN13: 9780471349914

ISBN10: 0471349917

Edition: 86

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Summary

This unique reference fills a void in the literature on clinical experimentation by focusing on principles that are especially useful in the design and analysis of studies on human subjects. It shows how to choose between modern and classical competing designs for a clinical study -- such as crossover designs, multicenter studies, and repeated measure experiments -- how to carry out each design and analyze the resulting data. Provides many practical examples, end-of-chapter problems and references, and solutions to each problem. The mathematical bases are given for several design strategies as well as for their analysis. Provides tables of critical values, 200 random permutations of the first one hundred integers, and an appendix on programmable methods for determining sample sizes.

Table of Contents

Table of Contents

1 Reliability of Measurement

2 Simple Linear Regression Analysis

3 The Parallel Groups Design

4 Special Cases of the Parallel Groups Study

5 Blocking to Control for Prognostic Variables

6 Stratification to Control for Prognostic Variables

7 Analysis of Covariance and the Study of Change

8 Repeated Measurements Studies

9 Latin and Greco-Latin Squares

10 The Crossover Study

11 Balanced Incomplete Block Designs

12 Factorial Experiments

13 Split-Plot Designs and Confounding



Appendix : Sample-Size Determination
Author Index
Subject Index