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Developmental Biology - With 2 CD's

Developmental Biology - With 2 CD's - 7th edition

Developmental Biology - With 2 CD's - 7th edition

ISBN13: 9780878932610

ISBN10: 0878932615

Developmental Biology - With 2 CD
Edition: 7TH 03
Copyright: 2003
Publisher: Sinauer Associates, Inc.
International: No
Developmental Biology - With 2 CD

ISBN13: 9780878932610

ISBN10: 0878932615

Edition: 7TH 03
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Developmental Biology, Seventh Edition captures the richness, the intellectual excitement, and the wonder of contemporary developmental biology. It is written primarily for undergraduate biology majors but will be useful for introducing graduate students and medical students to developmental biology. In addition to exploring and synthesizing the organismal, cellular, and molecular aspects of animal development, the Seventh Edition expands its coverage of the medical, environmental, and evolutionary aspects of developmental biology.


A completely updated text (see annotated Contents) integrates classical developmental biology with contemporary techniques, including the new material on vertebrate limb cell specification, microarrays, RNA interference, microtubular motors, floxed genes, vertebra formation, neural crest differentiation, neural crest specification, heart cell specification, herbicide-induced gonadal disruptions, pancreatic development, digit determination, tadpole deiodinases, insulin-like growth factors, developmental symbioses, and the developmental origins of feathers, jaws, and teeth during evolution.

A new chapter on medical implications of developmental biology The news is full of developmental biology and its medical implications. Therapeutic cloning and cancer therapies, in vitro fertilization, congenital anomalies, and teratogenesis are major concerns not only of scientists but of all citizens. Chapter 21, "Medical Implications of Human Development," brings these topics together and discusses:

  • the regulation of fertility
  • the identification of genetic defects that affect development
  • the identification of teratogenic compounds that affect development
  • the identification of factors in the maternal environment which may influence the health of the fetus or the adult
  • the realization that cancers can be disruptions of developmental regulation and might be cured through developmental processes
  • the attempts to cure developmental diseases (including cancers) through detection, cloning, stem cell therapy, and genetic engineering
  • the attempt to cure traumatic and degenerative disease through regeneration.

Author Bio

Gilbert, Scott F. : Swarthmore College

Scott F. Gilbert, the Howard A. Schneiderman Professor of Biology at Swarthmore College, teaches developmental biology, developmental genetics, and the history of biology. After receiving his B.A. from Wesleyan University, he pursued his graduate and postdoctoral research at The Johns Hopkins University and the University of Wisconsin. Dr. Gilbert is the recipient of several awards, including the first Viktor Hamburger Award for excellence in developmental biology education, an honorary degree from the University of Helsinki, and the Medal of François I from the Collège de France. He is a fellow of the American Association for the Advancement of Science, and a corresponding member of the St. Petersburg Society of Naturalists. His research is sponsored by the National Science Foundation and involves the developmental genetic mechanisms by which the turtle forms its shell.

Singer, Susan R. : Carleton College

Susan R. Singer, author of Chapter 20, "An Overview of Plant Development," is Professor of Biology and Director of the Perlman Center for Learning and Teaching at Carleton College. She earned a B.S., M.S., and Ph.D., all at Rensselaer Polytechnic Institute. Dr. Singer has chaired the Education Committee of the American Society of Plant Biologists and served as Program Director in Developmental Mechanisms at the National Science Foundation, and is currently a member of the National Research Council's Committee on Undergraduate Science Education. Her research interests, supported by NSF grants, include flowering and the developmental regulation of inflorescence architecture.

Both Scott and Susan are members of the Education Committee of the Society for Developmental Biology.

Table of Contents

Table of Contents

Numbered chapter titles are followed by some of the new material included in these chapters since the last edition.


Developmental Biology: The Anatomical Tradition
Life Cycles and the Evolution of Developmental Patterns
differentiation and cell adhesion in Dictyostelium
Principles of Experimental Embryology
the developmental mechanisms thought responsible for declining amphibian populations
The Genetic Core of Development
updates on mammalian cloning, embryonic and adult stem cells
mechanisms of transcriptional and translational gene regulation
macroarrays and microarrays
RNA interference technology
The Paradigm of Differential Gene Expression
histone modifications
"floxed" genes
X-chromosome inactivation
alternative RNA splicing
Cell-Cell Communication in Development
lens induction proteins
apoptosis pathways
new signal transduction pathways


Fertilization: Beginning a New Organism
new information on the control of the sea urchin acrosome reaction
phospholipase C and egg activation
rho proteins in fertilization, neural crest cell migration, and somitogenesis
mammalian sperm capacitation
gamete fusion proteins
roles of calcium in egg activation
reinitiation of DNA and protein synthesis at fertilization
sperm mitochondrial destruction
Early Development in Selected Invertebrates
transcriptional circuits in sea urchin specification and differentiation
MAP kinase activation and centrosome-associated mRNAs in snail cell determination
muscle determinants in the ascidian yellow crescent
PAR proteins in C. elegans
microtubular motors in insect egg polarity
homeodomain protein function
The Genetics of Axis Specification in Drosophila
cell polarity and cytoskeletal transport of transcription and paracrine factors
Early Development and Axis Formation in Amphibians
vegetal rotation in Xenopus
mechanisms of convergent extension
Nodal-related proteins in amphibian mesoderm induction
insulin-like growth factors in Xenopus head induction and C. elegans aging
The Early Development of Vertebrates: Fish, Birds, and Mammals
the new studies on ß-catenins in axis formation
homologies of fish and mammalian development
formation and functions of the fish embryonic shield
BMP inhibitors of the primitive streak
paracrine signaling from Hensen's node
cleavage and dorsal-ventral patterning in mammals
formation of the anterior visceral endoderm in mammals


The Emergence of the Ectoderm: The Central Nervous System and the Epidermis
important new material concerning the induction of neural crest cells
melanoblast migration
human-specific brain development
roles of folate in neural tube closure
neural stem cells
signaling pathways and developmental genetics of hair formation
mechanisms of neural plasticity
Neural Crest Cells and Axonal Specificity
specification, potentiality, and differentiation of neural crest cells, formation of bone from neural crest cells
Hox expression in neural crest cells
cranial placodes and their innervation
motor neuron determination
ephrin signaling
retinal specification
Paraxial and Intermediate Mesoderm
somite specification and epithelialization
Notch pathway, ephrins, and somite separation
mesodermal Hox expression and somite fate
vertebra formation
VEGF and bone formation
paraxial mesoderm signals to intermediate mesoderm
Hox and Pax factors in kidney specification
BMPs and collagen XVIII as critical for renal branching
the pretubular condensate as critical step in nephron development
GDNF in brain, sperm, and kidney development
Lateral Plate Mesoderm and Endoderm
specification of heart cells by BMPs and FGFs
the new cardiac fate map
initiation of first heartbeats
zebrafish cardiogenesis mutations
specification of cardiac chambers
angiogenesis in cancer and bone formation
artery specification and induction of veins
hematopoietic stem cells
endostatin and other anti-angiogenesis factors
specification of the vertebrate gut
the role of vasculature in pancreas and liver formation
Development of the Tetrapod Limb
the new controversies concerning vertebrate limb progress zone
Gli proteins and BMPs in digit determination
specification of the ZPA and AER
roles of BMP inhibitors to allow webbing
Sex Determination
possible Sry, Sox9, Fgf9, and Wnt4 functions in mammalian sex determination
functions of Doublesex in Drosophila sex determination
brain aromatase in turtle sex determination
atrazine and gonadal dysmorphogenesis in frogs
Metamorphosis, Regeneration, and Aging
deiodinases in frog metamorphosis
mechanisms of ecydysone action
modification of wing pathways in ant castes
signals for larval organ death
FGF requirements for amphibian limb regeneration
transdifferentiation in regeneration
Wnt pathways and hypostome genes in hydra regeneration
conserved insulin-like pathway for longevity
The Saga of the Germ Line
mammalian germ cell specification
migration pathway for mammalian PGC migration
core meiotic recombination complex
germ-cell formation in Drosophila and C. elegans


An Overview of Plant Development
mechanism of self-self incompatibility blocking self fertilization in brassicas
development of dorsal ventral asymmetry in leaves
role of KNOX genes in the evolution of compound leaf development
evolution of the development of asymmetry in flowers
New Chapter! -- Medical Implications of Human Development -- (see topics under "About this Title")
Environmental Regulation of Animal Development
recent discoveries in developmental symbioses, including the activation of mammalian regulatory genes by bacteria and the completion of oogenesis through symbionts
embryonic diapause
stress-induced gene expression
caste determination in ants
peptides mediating fish sex changes
mechanisms of environmental endocrine disruption
predator and competitor-induced polyphenisms
Developmental Mechanisms of Evolutionary Change
developmental origins of jaws, feathers and teeth
gene duplication, redeployment of genes and pathways for evolutionary novelties
developmental constraints and canalization
the importance of the neural crest in vertebrate evolution
why insects have only six legs

Other Editions of Developmental Biology - With 2 CD's

Developmental Biology -With CD by Scott F. Gilbert - ISBN 9780878932504