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Developmental Biology -With CD

Developmental Biology -With CD - 8th edition

Developmental Biology -With CD - 8th edition

ISBN13: 9780878932504

ISBN10: 087893250X

Developmental Biology -With CD by Scott F. Gilbert - ISBN 9780878932504
Cover type: Hardback
Edition: 8TH 06
Copyright: 2006
Publisher: Sinauer Associates, Inc.
International: No
Developmental Biology -With CD by Scott F. Gilbert - ISBN 9780878932504

ISBN13: 9780878932504

ISBN10: 087893250X

Cover type: Hardback
Edition: 8TH 06

List price: $119.95

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Developmental Biology captures the richness, the intellectual excitement, and the wonder of contemporary developmental biology. It is written for junior- and senior-level undergraduates who have taken a course in either cell biology or genetics. In addition to exploring and synthesizing the organismal, cellular, and molecular aspects of animal development, expands its coverage of the medical, environmental, and evolutionary aspects of developmental biology.

Table of Contents

Table of Contents

PART I. An Introduction to Developmental Biology
1. An introduction to animal development

The scope of developmental biology
The problems of developmental biology
The stages of animal development
Our eukaryotic heritage
Development among the unicellular eukaryotes
Control of Developmental Morphogenesis in Acetabularia
Differentiation in the Amoeboflagellate Naegleria
The Origins of Sexual Reproduction
Colonial eukaryotes: The evolution of
The Volvocaceans
Sidelights & Speculations: Sex and
Individuality in Volvox
Differentiation and Morphogenesis in
Sidelights & Speculations: Evidence and Antibodies
Sidelights & Speculations: How the Grex
Knows Which End Is Up
Developmental patterns among the metazoans
The Porifera
Protostomes and Deuterostomes

2. Genes and development: Introduction and techniques

The embryological origins of the gene theory
Nucleus or Cytoplasm: Which Controls Heredity?
The X Chromosome as Bridge Between Genes
and Development
The split between embryology and genetics
Early attempts at developmental genetics
Evidence for genomic equivalence
Amphibian Cloning: The Restriction of Nuclear Potency
Amphibian Cloning: The Pluripotency of
Somatic Cells
Sidelights & Speculations: Cloning Mammals for Fun and Profit
Of E. coli and elephants: The operon model
Differential RNA synthesis
Nucleic acid hybridization
Cloning from genomic DNA
DNA hybridization: Within and across species
DNA sequencing
Analyzing mRNA through cDNA libraries
RNA localization techniques
In Situ Hybridization
Northern Blots
Finding rare messages by the polymerase
chain reaction
Determining the function of a gene:
Transgenic cells and organisms
Techniques of Inserting New DNA Into a
Chimeric Mice
Gene-Targeting ("Knockout") Experiments
Determining the function of a message: Antisense RNA
Reinvestigation of old problems with new
A conclusion and a caveat

3. The cellular basis of morphogenesis:

Differential cell affinity
Differential cell affinity
The Thermodynamic Model of Cell
Sidelights & Speculations: Evidence for the
Thermodynamic Model
The molecular basis of cell-cell adhesions
The Classes of Cell Adhesion Molecules
Sidelights & Speculations: Monoclonal Antibodies and Reverse Genetics
Cell adhesion molecules
Identifying Cell Adhesion Molecules and
Their Role in Development
Immunoglobulin Superfamily CAMs
Cell junctional molecules: Gap junction proteins
The molecular basis of cell-substrate affinity
Differential Substrate Affinity
The Extracellular Matrix
Cell Receptors for the Extracellular
Matrix Molecules
Differential Adhesion Resulting from
Multiple Adhesion Systems
Receptor molecules and signal transduction pathways
The JAK-STAT Pathway
The RTK-Ras Pathway
Sidelights & Speculations: Dominant
Negative Receptor Mutations
The Inositol Phosphate Pathway
Cross-Talk Between Pathways
The Extracellular Matrix and Cell Surface
as Sources of Developmentally Critical Signals
Reciprocal Interactions at the Cell Surface

PART II Patterns of Development
4. Fertilization: Beginning a new organism

Structure of the gametes
The Egg
Recognition of egg and sperm: Action at a
Sperm Attraction
Sperm Activation: The Acrosome Reaction
in Sea Urchins
Sidelights & Speculations: Action at a
Distance: Mammalian Gametes
Recognition of Egg and Sperm: Contact of Gametes
Species-Specific Recognition in Sea Urchins
Gamete Binding and Recognition in Mammals
Gamete fusion and the prevention of polyspermy
Fusion Between Egg and Sperm Cell
Prevention of Polyspermy
Sidelights & Speculations: The Activation
of Gamete Metabolism
Activation of egg metabolism
Early Responses
Late Responses
Fusion of the Genetic Material
Sidelights & Speculations: The
Nonequivalence of Mammalian Pronuclei
Rearrangement of egg cytoplasm
Preparation for Cleavage

5. Cleavage: Creating multicellularity

Radial holoblastic cleavage
The Sea Cucumber, Synapta
Sea Urchins
Spiral holoblastic cleavage
Sidelights & Speculations: Adaptation by
Modifying Embryonic Cleavage
Bilateral Holoblastic Cleavage
Rotational holoblastic cleavage
Sidelights & Speculations: The Cell Surface
and the Mechanism of Compaction
Formation of the Inner Cell Mass
Escape from the Zona Pellucida
Sidelights & Speculations: Twins and
Embryonic Stem Cells
Meroblastic cleavage
Discoidal Cleavage
Superficial Cleavage
Sidelights & Speculations: Exceptions,
Generalizations, and Parasitic Wasp Cleavage


Regulating the cleavage cycle
Maturation-Promoting Factor
Sidelights & Speculations: MFP and Its Regulators
The cytoskeletal mechanisms of mitosis
The formation of new membranes

6. Gastrulation: Reorganizing the embryonic

Sea urchin gastrulation
Ingression of Primary Mesenchyme
First Stage of Archenteron Invagination
Second and Third Stages of Archenteron
Gastrulation in fish
The Midblastula Transition and the
Acquisition of Cell Motility
Formation of Germ Layers
Amphibian gastrulation
Cell Movements During Amphibian Gastrulation
Positioning the Blastopore
Cell Movements and the Construction of the Archenteron
Migration of the Involuting Mesoderm
Sidelights & Speculations: Molecular
Regulators of Development: Fibronectin and
the Pathways for Mesodermal Migration
Epiboly of the Ectoderm
Gastrulation in birds
Overview of Avian Gastrulation
Mechanisms of Avian Gastrulation
Gastrulation in mammals
Modifications for Development Within Another Organism
Formation of Extraembryonic Membranes

7. Early vertebrate development: Neurulation and the ectoderm

Neurulation: An overview
Primary neurulation
The Mechanics of Primary Neurulation
The Formation of the Neural Plate
Formation of the Neural Floor Plate
The Shaping and Bending of the Neural Plate
Closure of the Neural Tube
Sidelights & Speculations: The
Dorsal-Ventral Patterning of the Nervous System
Secondary neurulation
Differentiation of the neural tube
Formation of Brain Regions
Sidelights & Speculations: Determining the
Forebrain and Midbrain Regions
Tissue Architecture of the Central Nervous System
Cerebellar Organization
Cerebral Organization
Neuronal types
Development of the vertebrate eye
Dynamics of Optic Development
Neural Retina Differentiation
Sidelights & Speculations: Why Babies Don't See Well
Lens and Cornea Differentiation


The neural crest and its derivatives
The trunk neural crest
Migration Pathways of Trunk Neural Crest
The Extracellular Matrix and Trunk Neural
Crest Migration
Sidelights & Speculations: Analysis of
Mutations Affecting Neural Crest Cell
The developmental potency of trunk neural
crest cells
Final Differentiation of the Neural Crest
The cephalic neural crest
Migratory Pathways of the Cephalic Neural
Crest Cells
Developmental Potency of the Cephalic
Neural Crest Cells
The cardiac neural crest


The Origin of Epidermal Cells
Cutaneous Appendages

8. Axonal specificity

The generation of neuronal diversity
Vertebrate Motor Neuron Specification
Motor Neuron Specification in Drosophila
Pattern formation in the nervous system
Pathway selection: Guidance by the
extracellular matrix
Guidance by the Physical Terrain: Contact Guidance
Guidance by Adhesive Gradients: Haptotaxis
Guidance by Axon-Specific Migratory Cues:
The Labeled Pathways Hypothesis
Guidance by Specific Growth Cone Repulsion
Sidelights & Speculations: Sex, Smell, and Specific Adhesion
Pathway selection: Guidance by diffusible
Multiple guidance cues
Vertebrate Motor Neurons
Retinal Axons
Target selection
Adhesive Specificities in Different Regions of the Tectum
Address selection: Activity-dependent
Differential survival after innervation: Neurotrophic factors
Sidelights & Speculations: Fetal Neurons in Adult Hosts
The development of behaviors: Constancy and plasticity

9. Early vertebrate development: Mesoderm and endoderm

Dorsal mesoderm: The notochord and the
differentiation of somites
Paraxial Mesoderm
Somitomeres and the Initiation of Somite Formation
Generation of the Somitic Cell Types
Myogenesis: Differentiation of Skeletal
Sidelights & Speculations: Muscle Building
and the MyoD Family of Transcriptional Regulators
Osteogenesis: The Development of Bones
Sidelights & Speculations: Control of
Chondrogenesis at the Growth Plate
Lateral plate mesoderm
Formation of Extraembryonic Membranes
The Heart
Formation of Blood Vessels
Sidelights & Speculations: Redirecting
Blood Flow in the Newborn Mammal
The development of blood cells
The Stem Cell Concept
Pluripotential Stem Cells and
Hematopoietic Microenvironments
Osteoclast Development
Sites of Hematopoiesis