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Macroscale and Microscale Organic Experiments

Macroscale and Microscale Organic Experiments - 3rd edition

Macroscale and Microscale Organic Experiments - 3rd edition

ISBN13: 9780395902202

ISBN10: 0395902207

Macroscale and Microscale Organic Experiments by Kenneth L. Williamson - ISBN 9780395902202
Cover type: Hardback
Edition: 3RD 99
Copyright: 1999
Publisher: Houghton Mifflin Harcourt
International: No
Macroscale and Microscale Organic Experiments by Kenneth L. Williamson - ISBN 9780395902202

ISBN13: 9780395902202

ISBN10: 0395902207

Cover type: Hardback
Edition: 3RD 99

List price: $120.00

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This best-selling lab manual for one- and two-semester organic chemistry courses offers a series of clear and concise experiments - with macroscale and microscale procedures for each - that encourage accurate observation and the development of deductive reasoning. The author places strong emphasis on safety and the responsible disposal of hazardous waste.

  • New! Extensive references to relevant Web sites can be found in a feature called "Surfing the Web" at the end of relevant chapters.
  • New! For selected experiments, a feature called "For Further Investigation" provides optional, additional procedures that students can perform to further explore the chemical principle being presented.
  • New! A section on computational chemistry has been added to relevant experiments. These computer-based calculations are used to determine the precise structure of molecules.
  • New! The order of the chapters has been changed to follow that of most organic textbooks. Similar types of experiments are now grouped together.
  • New! Experiments now make use of much cheaper and safer solvents.
  • New! Chapters on Molecular Mechanics and NMR Spectroscopy have been rewritten and exercises have been added.
  • New! Three new experiments have been added - Experiments 34, 57, and 57 - respectively, "1,2,3,4-Tetraphenylnaphthalene via Benzyne," "Synthesis of 2,2-Dimethyl-1,5-dioxolane. The Acetonide Derivative of a Vicinal Diol,", and "Isolation of Lycopene and B-Carotene."
  • At the end of every experiment, a "Cleaning Up" section instructs students on how to safely dispose of all by-products of the experiment.
  • Each experiment includes information on the time needed to carry out the experiment, as well as the degree of difficulty of the experiment.
  • Experiments in this manual have been performed by literally thousands of students over the years and are proven to work.
  • Other pedagogical features include prelab exercises, marginal notes, clear line drawings, and questions for students, with answers provided in the Instructor's Resource Manual.

Table of Contents

Table of Contents

1. Introduction
2. Laboratory Safety and Waste Disposal


3. Crystallization
4. Melting Points, Boiling Points, and Refractive Indices
5. Distillation
6. Steam Distillation
7. Vacuum Distillation and Sublimation
8. Extraction of Acids and Bases and the Isolation of Caffeine from Coffee, Tea, and Cola Syrup
9. Thin-Layer Chromatography: Analysis of Analgesics and Isolation of Lycopene from Tomato Paste
10. Column Chromatography: Acetylferrocene, Cholesteryl Acetate, and Fluorenone
11. Alkenes from Alcohols: Analysis of a Mixture by Gas Chromatography
12. Infrared Spectroscopy
13. Nuclear Magnetic Resonance Spectroscopy
14. Ultraviolet Spectroscopy
15. Molecular Mechanics and Computational Chemistry

Elimination, Substitution, and Addition

16. The SN2 Reaction: 1-Bromobutane
17. Nucleophilic Substitution Reactions of Alkyl Halides
18. Alkanes and Alkenes: Radical Initiated Chlorination of 1-Chlorobutane; Reactions of Alkanes and Alkenes
19. Alkenes from Alcohols: Cyclohexene from Cyclohexanol
20. Bromination and Debromination: Purification of Cholesterol
21. Dichlorocarbene

Oxidation and Reduction

22. Oxidation: Cyclohexanol to Cyclohexanone; Cyclohexanone to Adipic Acid
23. Pulegone from Citronellol: Oxidation with Pyridinium Chlorochromate
24. Oxidative Coupling of Alkynes: 2,7-Dimethyl-3,5-octadiyn-2,7-diol
25. Catalytic Hydrogenation
26. Sodium Borohydride Reduction of 2-Methylcyclohexanone: A Problem in Conformational Analysis
27. Epoxidation of Cholesterol

Aromatic Substitution and Elimination

28. Nitration of Methyl Benzoate
29. Friedel-Crafts Alkylation of Benzene and Dimethoxybenzene; Host-Guest Chemistry
30. Alkylation of Mesitylene
31. Reactions of Triphenylmethyl Carbocation, Carbanion, and Radical
32. The Friedel-Crafts Reaction: Anthraquinone and Anthracene
33. Friedel-Crafts Acylation of Ferrocene: Acetylferrocene
34. 1,2,3,4-Tetraphenylnaphthalene via Benzyne
35. Triptycene via Benzyne

Reactions of Aldehydes and Ketones

36. Aldehydes and Ketones
37. Dibenzalacetone by the Aldol Condensation
38. Grignard Synthesis of Triphenylmethanol and Benzoic Acid
39. The Wittig and Wittig-Horner Reactions

Reactions of Carboxylic Acids, Esters and Amines

40. Esterification and Hydrolysis
41. Acetylsalicylic Acid (Aspirin)
42. Malonic Ester Synthesis: Synthesis of a Barbiturate
43. Amines
44. Separation and Purification of the Components of an Analgesic Tablet: Aspirin, Caffeine, and Acetaminophen
45. The Sandmeyer Reaction: 1-Bromo-4-chlorobenzene, 2-lodobenzoic Acid, and 4-Chlorotoluene
46. Sulfanilamide from Nitrobenzene
47. Dyes and Dyeing
48. Martius Yellow

The Diels-Alder and Related Reactions

49. Diels-Alder Reaction
50. Ferrocene, [Bis(cyclopentadienyl)iron]
51. p-Terphenyl by the Diels-Alder Reaction
52. Tetraphenylcyclopentadienone
53. Hexaphenylbenzene and Dimethyl Tetraphenylphthalate

Derivatives of 1,2-Diphenylethane: A Multistep Synthesis

54. The Benzoin Condensation: Cyanide Ion and Thiamine Catalyzed
55. Nitric Acid Oxidation. Preparation of Benzil from Benzoin. Synthesis of a Heterocycle: Diphenylquinoxaline
56. Borohydride Reduction of a Ketone: Hydrobenzoin from Benzil
57. Synthesis of 2,2-Dimethyl-1,5-dioxolane. The Acetonide Derivative of a Vicinal Diol
58. 1,4-Addition: Reductive Acetylation of Benzil
59. Synthesis of an Alkyne from an Alkene. Bromination and Dehydrobromination: Stilbene and Diphenylacetylene
60. The Perkin Reaction: Synthesis of [alpha]-Phenylcinnamic Acid
61. Decarboxylation: Synthesis of cis-Stilbene
62. Chemiluminescence: Syntheses of Cyalume and Luminol
63. Photochemistry: The Synthesis of Benzopinacol

Natural Product Chemistry and Biochemistry

64. Carbohydrates and Sweeteners
65. Biosynthesis of Ethanol
66. Enzymatic Reactions: A Chiral Alcohol from a Ketone and Enzymatic Resolution of DL-Alanine
67. Isolation of Lycopene and B-Carotene
68. The Synthesis of Natural Products: Pseudopellitierene and Camphor
69. Polymers: Synthesis and Recycling
70. Qualitative Organic Analysis
71. Searching the Chemical Literature